MLYS Mineralys Therapeutics, Inc. - Common Stock
$27.33
Price · Aug 19, 2026
Fundamentals as of Aug 11, 2026
52W Range
$14–$48
39% of range
Analyst Rating
BUY
16 analysts
Price Target
$48
+77% upside
P/E (TTM)
-12.1
ROE
-32.2%
Net Profit Margin
—
MLYS Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range
Price
$27.33
Market Cap
$2.25B
P/E (TTM)
-12.1
EPS (TTM)
$-2.29
Revenue (TTM)
—
Div Yield
—
ROE
-32.2%
Debt/Equity
—
52W Range
$14 – $48
MLYS Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view
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10-Year Performance Revenue, net income, margins and EPS trends
Revenue & Net Income
—
EPS
$-2.29
2022-12-31
→
2025-12-31
Free Cash Flow
$-142M
2024-12-31
→
2025-12-31
Margins
—
Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?
Metric
5Y trend
MLYS
Peer Median
P/E (TTM)
-12.1
55.4
P/B
3.5
7.1
Price / FCF
-15.8
—
Profitability Gross, operating and net margins; ROE, ROA, ROIC
Metric
5Y trend
MLYS
Peer Median
ROA
-35.6%
-32.7%
ROE
-32.2%
-37.9%
Financial Health Debt, liquidity, solvency — balance sheet strength
Metric
5Y trend
MLYS
Peer Median
Current Ratio
43.8
7.4
Quick Ratio
11.4
—
Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR
Metric
5Y trend
MLYS
Peer Median
Capital Efficiency Asset turnover, inventory turnover, receivables turnover
Metric
5Y trend
MLYS
Peer Median
MLYS Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside
BUY
16 analysts
- Strong Buy 5 31.2%
- Buy 9 56.2%
- Hold 2 12.5%
- Sell 0 0.0%
- Strong Sell 0 0.0%
12-Month Price Target
8 analysts · 2026-08-15
Median
$52.00
Mean
$48.50
← Below all targets
$27.33
Low
$30.00
High
$56.00
Median target
$52.00
+90.3%
Mean target
$48.50
+77.5%
Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date
Avg Surprise
-0.29%
| Period | EPS Actual | EPS Est | Surprise |
|---|---|---|---|
| June 30, 2026 | $-2.85 | $-0.55 | -2.3% |
| March 31, 2026 | $-0.47 | $-0.47 | 0.00% |
| Dec. 31, 2025 | $-0.40 | $-0.54 | 0.14% |
| Sept. 30, 2025 | $-0.52 | $-0.63 | 0.11% |
| June 30, 2025 | $-0.66 | $-0.73 | 0.07% |
| March 31, 2025 | $-0.79 | $-1.00 | 0.21% |
Peer comparison (GICS sub-industry) Key metrics vs sector peers
| Ticker | Market Cap | P/E | Rev YoY | Net Margin | ROE | Gross Margin |
|---|---|---|---|---|---|---|
| MLYS | $2.96B | -15.8 | — | — | -32.2% | — |
| KOD | $1.73B | -6.5 | — | — | -202.0% | — |
| BCRX | $1.66B | 6.4 | 94.1% | 30.2% | -97.6% | — |
| PGEN | $1.48B | -3.1 | 146.7% | -2588.2% | 3159.1% | — |
| CDNA | $959M | -47.1 | 13.8% | -5.6% | -6.8% | — |
| COAG | — | — | — | — | — | — |
| KLRA | — | — | — | — | — | — |
| VERA | — | -10.9 | — | — | -55.9% | — |
| VCEL | $1.82B | 112.5 | 16.4% | 6.0% | 5.0% | 74.4% |
| ADMA | $4.34B | 30.4 | 19.6% | 28.8% | 33.6% | 57.4% |
Full Fundamentals All metrics by year — income statement, balance sheet, cash flow
Income Statement 12
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| R&D Expense | $132M | $169M | $70M | $26M | |
| SG&A Expense | $39M | $24M | $14M | $5M | |
| Operating Expenses | $171M | $192M | $85M | $31M | |
| Operating Income | $-171M | $-192M | $-85M | $-31M | |
| Other Non-op | $0 | $5.0K | $3.0K | $2M | |
| Income Tax | $0 | · | · | · | |
| Net Income | $-155M | $-178M | $-72M | $-30M | |
| EPS (Basic) | $-2.29 | $-3.66 | $-1.99 | $-5.77 | |
| EPS (Diluted) | $-2.29 | $-3.66 | $-1.99 | $-5.77 | |
| Shares (Basic) | 67,656,355 | 48,539,795 | 36,188,254 | 5,167,296 | |
| Shares (Diluted) | 67,656,355 | 48,539,795 | 36,188,254 | 5,167,296 | |
| EBITDA | $-171M | $-192M | $-85M | · |
Balance Sheet 16
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Cash & Equivalents | $173M | $114M | $49M | $88M | |
| Prepaid Expense | $5M | $7M | $13M | $3M | |
| Current Assets | $661M | $205M | $249M | $113M | |
| PP&E (Net) | $38.0K | $53.0K | $0 | · | |
| Other Non-current Assets | $382.0K | $499.0K | $51.0K | $2M | |
| Total Assets | $662M | $206M | $252M | $114M | |
| Accounts Payable | $2M | $479.0K | $601.0K | $2M | |
| Accrued Liabilities | $13M | $14M | $10M | $6M | |
| Current Liabilities | $15M | $15M | $10M | $8M | |
| Total Liabilities | $15M | · | · | · | |
| Common Stock | $8.0K | $5.0K | $4.0K | $1.0K | |
| Paid-in Capital | $1.10B | $494M | $366M | $540.0K | |
| Retained Earnings | $-457M | $-303M | $-125M | $-53M | |
| Stockholders' Equity | $647M | $191M | $241M | $-52M | |
| Liabilities + Equity | $662M | $206M | $252M | $114M | |
| Shares Outstanding | 81,536,557 | 49,821,915 | 41,133,916 | 6,419,238 |
Cash Flow 10
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| D&A | $59.0K | $43.0K | $0 | · | |
| Stock-based Comp | $19M | $11M | $5M | $455.0K | |
| Deferred Tax | $0 | $0 | $0 | $0 | |
| Other Non-cash | $-7M | $117.0K | · | · | |
| Operating Cash Flow | $-142M | $-166M | $-81M | $-29M | |
| CapEx | $15.0K | $96.0K | $0 | · | |
| Investing Cash Flow | $-390M | $115M | $-160M | $-22M | |
| Financing Cash Flow | $591M | $116M | $203M | $128M | |
| Net Change in Cash | $59M | $65M | $-38M | $77M | |
| Free Cash Flow | $-142M | $-166M | · | · |
Profitability 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| ROA | -35.6% | -77.7% | -39.3% | · | |
| ROE | -32.2% | -83.0% | -28.5% | · |
Liquidity & Solvency 2
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Current Ratio | 43.8 | 14.0 | 23.8 | · | |
| Quick Ratio | 11.4 | 7.8 | 4.7 | · |
Valuation (TTM) 8
| Metric | Trend | 2025 | 2024 | 2023 | 2022 |
|---|---|---|---|---|---|
| Net Income TTM | $-155M | $-178M | $-72M | $-30M | |
| Market Cap | $2.96B | $613M | $354M | · | |
| P/E | -15.8 | -3.4 | -4.3 | · | |
| P/B | 4.6 | 3.2 | 1.5 | · | |
| P / Tangible Book | 4.6 | 3.2 | 1.5 | · | |
| P / Cash Flow | -20.8 | -3.7 | -4.4 | · | |
| P / FCF | -20.8 | -3.7 | · | · | |
| Earnings Yield | -6.3% | -29.7% | -23.1% | · |
Income Statement 12
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $221M | $24M | $24M | $31M | $38M | $38M | $45M | $54M | $39M | $31M | $24M | $22M | $12M | $12M | $8M | |
| SG&A Expense | $25M | $21M | $14M | $10M | $8M | $7M | $7M | $6M | $6M | $5M | $4M | $4M | $4M | $3M | $2M | |
| Operating Expenses | $246M | $45M | $38M | $41M | $47M | $44M | $52M | $60M | $45M | $35M | $28M | $26M | $16M | $15M | $10M | |
| Operating Income | $-246M | $-45M | $-38M | $-41M | $-47M | $-44M | $-52M | $-60M | $-45M | $-35M | $-28M | $-26M | $-16M | $-15M | $-10M | |
| Other Non-op | $13.0K | $5.0K | $1.0K | $4.0K | $-2.0K | $-3.0K | $12.0K | $-10.0K | $2.0K | $1.0K | $-6M | $0 | $4M | $2M | $935.0K | |
| Income Tax | · | · | $0 | · | · | · | · | · | · | · | · | · | · | · | · | |
| Net Income | $-241M | $-39M | $-32M | $-37M | $-43M | $-42M | $-49M | $-56M | $-41M | $-32M | $-24M | $-23M | $-12M | $-13M | $-9M | |
| EPS (Basic) | $-2.85 | $-0.47 | $-0.32 | $-0.52 | $-0.66 | $-0.79 | $-1.00 | $-1.13 | $-0.83 | $-0.70 | $-0.60 | $-0.57 | $-0.31 | $-0.51 | $-1.74 | |
| EPS (Diluted) | $-2.85 | $-0.47 | $-0.32 | $-0.52 | $-0.66 | $-0.79 | $-1.00 | $-1.13 | $-0.83 | $-0.70 | $-0.60 | $-0.57 | $-0.31 | $-0.51 | $-1.74 | |
| Shares (Basic) | 84,727,282 | 82,834,752 | -121,552,997 | 70,594,504 | 65,451,297 | 53,163,551 | -95,532,433 | 49,815,186 | 49,356,287 | 44,900,755 | -68,261,944 | 39,930,748 | 39,754,981 | 24,764,469 | -10,290,323 | |
| Shares (Diluted) | 84,727,282 | 82,834,752 | -121,552,997 | 70,594,504 | 65,451,297 | 53,163,551 | -95,532,433 | 49,815,186 | 49,356,287 | 44,900,755 | -68,261,944 | 39,930,748 | 39,754,981 | 24,764,469 | -10,290,323 | |
| EBITDA | $-246M | $-45M | · | $-41M | $-47M | $-44M | · | $-60M | $-45M | $-35M | · | $-26M | $-16M | $-15M | · |
Balance Sheet 17
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $138M | $113M | $173M | $218M | $102M | $165M | $114M | $97M | $68M | $90M | $49M | $86M | $101M | $138M | $88M | |
| Prepaid Expense | $4M | $6M | $5M | $6M | $10M | $11M | $7M | $4M | $7M | $8M | $13M | $12M | $8M | $5M | $3M | |
| Current Assets | $666M | $652M | $661M | $600M | $335M | $355M | $205M | $268M | $318M | $347M | $249M | $265M | $269M | $275M | $113M | |
| PP&E (Net) | $27.0K | $32.0K | $38.0K | $7.0K | $22.0K | $38.0K | $53.0K | $69.0K | $42.0K | $51.0K | $0 | · | · | · | · | |
| Other Non-current Assets | $2M | $360.0K | $382.0K | $144.0K | $433.0K | $397.0K | $499.0K | $452.0K | $449.0K | $379.0K | $51.0K | $51.0K | $51.0K | $39.0K | $2M | |
| Total Assets | $668M | $653M | $662M | $600M | $336M | $355M | $206M | $268M | $318M | $347M | $252M | $278M | $291M | $306M | $114M | |
| Accounts Payable | $1M | $1M | $2M | $1M | $3M | $373.0K | $479.0K | $3M | $2M | $4M | $601.0K | $6M | $2M | $2M | $2M | |
| Accrued Liabilities | $18M | $14M | $13M | $22M | $19M | $13M | $14M | $28M | $27M | $15M | $10M | $8M | $4M | $8M | $6M | |
| Current Liabilities | $19M | $15M | $15M | $24M | $22M | $13M | $15M | $31M | $28M | $19M | $10M | $14M | $6M | $11M | $8M | |
| Total Liabilities | $117M | · | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| Long-term Debt | $100.0K | · | · | · | · | · | · | · | · | · | · | · | · | · | · | |
| Common Stock | $9.0K | $8.0K | $8.0K | $8.0K | $6.0K | $6.0K | $5.0K | $5.0K | $5.0K | $5.0K | $4.0K | $4.0K | $4.0K | $4.0K | $1.0K | |
| Paid-in Capital | $1.29B | $1.13B | $1.10B | $1.00B | $702M | $686M | $494M | $490M | $487M | $484M | $366M | $364M | $363M | $361M | $540.0K | |
| Retained Earnings | $-738M | $-497M | $-457M | $-425M | $-388M | $-345M | $-303M | $-254M | $-197M | $-156M | $-125M | $-100M | $-78M | $-65M | $-53M | |
| Stockholders' Equity | $551M | $638M | $647M | $576M | $314M | $342M | $191M | $237M | $290M | $328M | $241M | $264M | $285M | $296M | $-52M | |
| Liabilities + Equity | $668M | $653M | $662M | $600M | $336M | $355M | $206M | $268M | $318M | $347M | $252M | $278M | $291M | $306M | $114M | |
| Shares Outstanding | 88,351,196 | 82,454,950 | 81,536,557 | 78,969,459 | 65,725,409 | 64,876,228 | 49,821,915 | 49,755,946 | 49,710,598 | 49,632,989 | 41,133,916 | 41,105,118 | 40,856,653 | 40,856,653 | 6,419,238 |
Cash Flow 11
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $5.0K | $6.0K | $13.0K | $15.0K | $16.0K | $15.0K | $15.0K | $11.0K | $9.0K | $8.0K | $0 | $0 | $0 | $0 | · | |
| Stock-based Comp | $7M | $7M | $5M | $6M | $5M | $4M | $3M | $3M | $3M | $2M | $1M | $2M | $1M | $749.0K | $218.0K | |
| Other Non-cash | · | $-7M | · | · | · | $-7M | · | · | · | $10M | · | · | · | · | · | |
| Operating Cash Flow | $-33M | $-39M | $-38M | $-29M | $-30M | $-45M | $-67M | $-50M | $-30M | $-19M | $-29M | $-19M | $-20M | $-13M | $-10M | |
| CapEx | · | · | $15.0K | $0 | $0 | $0 | $0 | $37.0K | $0 | $59.0K | $0 | $0 | $0 | $0 | · | |
| Investing Cash Flow | $-185M | $-45M | $-103M | $-151M | $-43M | $-93M | $84M | $80M | $8M | $-56M | $-8M | $4M | $-16M | $-140M | $50M | |
| Stock Issued | · | · | · | · | · | $189M | · | · | · | $0 | · | $0 | $-581.0K | $204M | · | |
| Net Stock Activity | · | · | · | · | · | $189M | · | · | · | · | · | · | · | $204M | · | |
| Financing Cash Flow | $243M | $24M | $97M | $295M | $10M | $189M | $90.0K | $-1.0K | $-152.0K | $116M | $74.0K | $184.0K | $-581.0K | $204M | $-1M | |
| Net Change in Cash | $25M | $-60M | $-45M | $116M | $-63M | $51M | $17M | $29M | $-23M | $41M | $-37M | $-15M | $-37M | $51M | $39M | |
| Free Cash Flow | · | · | · | · | · | $-45M | · | · | · | $-19M | · | · | · | · | · |
Profitability 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -48.0% | -7.8% | · | -8.5% | -13.2% | -12.0% | · | -20.6% | -13.5% | -9.6% | · | -16.4% | -8.3% | -8.2% | · | |
| ROE | -55.8% | -8.0% | · | -9.1% | -14.3% | -12.6% | · | -22.5% | -14.3% | -10.1% | · | -17.2% | -8.5% | -8.5% | · |
Liquidity & Solvency 2
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 34.5 | 44.3 | · | 25.5 | 15.1 | 26.5 | · | 8.5 | 11.2 | 18.1 | · | 19.6 | 43.4 | 26.1 | · | |
| Quick Ratio | 7.2 | 7.7 | · | 9.3 | 4.6 | 12.3 | · | 3.1 | 2.4 | 4.7 | · | 6.4 | 16.3 | 13.1 | · |
Valuation (TTM) 8
| Metric | Trend | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-361M | $-162M | · | $-179M | $-183M | $-171M | · | $-152M | $-107M | $-79M | · | $-54M | $-38M | $-33M | · | |
| Market Cap | $2.38B | $2.23B | · | $2.99B | $889M | $1.03B | · | $603M | $582M | $641M | · | $391M | $697M | $640M | · | |
| P/E | -6.0 | -11.1 | · | -12.2 | -4.0 | -4.6 | · | -3.7 | -4.9 | -6.2 | · | -3.5 | -5.1 | -3.4 | · | |
| P/B | 4.3 | 3.5 | · | 5.2 | 2.8 | 3.0 | · | 2.5 | 2.0 | 2.0 | · | 1.5 | 2.4 | 2.2 | · | |
| P / Tangible Book | 4.3 | 3.5 | · | 5.2 | 2.8 | 3.0 | · | 2.5 | 2.0 | 2.0 | · | 1.5 | 2.4 | 2.2 | · | |
| P / Cash Flow | · | -56.6 | · | · | · | -22.6 | · | · | · | -33.5 | · | · | · | -50.1 | · | |
| P / FCF | · | · | · | · | · | -22.6 | · | · | · | -33.4 | · | · | · | · | · | |
| Earnings Yield | -16.7% | -9.0% | · | -8.2% | -25.2% | -21.7% | · | -26.7% | -20.6% | -16.2% | · | -28.2% | -19.8% | -29.0% | · |
Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years
Income Statement
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Net Income | $-155M | $-178M | $-72M | $-30M |
| Diluted EPS | $-2.29 | $-3.66 | $-1.99 | $-5.77 |
Balance Sheet
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Current Ratio | 43.8 | 14.0 | 23.8 | — |
| Quick Ratio | 11.4 | 7.8 | 4.7 | — |
Cash Flow
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | |
|---|---|---|---|---|
| Free Cash Flow | $-142M | $-166M | — | — |
Latest News Recent headlines mentioning this company
Trading Signals Recent buy/sell signals with entry price and risk/reward ratio
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Institutional owners (13F) 250 filers · $2.4B total · As of June 30, 2026
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
Institutional activity — Q2 2026 vs prior quarter
| New positions | Exited positions | Increased | Decreased | Net shares change |
|---|---|---|---|---|
| 46 (+15 vs prior Q) | 21 (-15 vs prior Q) | 79 (-19 vs prior Q) | 66 (+13 vs prior Q) | +6.7M |
Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| Catalys Pacific, LLC | $213,245,549 | 7,903,838 | 9.02% | Shares |
| RA CAPITAL MANAGEMENT, L.P. | $207,550,395 | 7,692,750 | 8.78% | Shares |
| SAMSARA BIOCAPITAL, LLC | $158,400,066 | 5,871,018 | 6.70% | Shares |
| STATE STREET CORP | $111,741,339 | 4,141,636 | 4.73% | Shares |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $106,786,840 | 3,958,000 | 4.52% | Shares |
| FMR LLC | $101,995,543 | 3,780,413 | 4.31% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $74,377,655 | 2,756,770 | 3.15% | Shares |
| Laurion Capital Management LP | $67,615,981 | 2,506,152 | 2.86% | Shares |
| ORBIMED ADVISORS LLC | $56,935,894 | 2,110,300 | 2.41% | Shares |
| Capital World Investors | $53,895,437 | 1,997,607 | 2.28% | Shares |
| ARMISTICE CAPITAL, LLC | $46,837,280 | 1,736,000 | 1.98% | Shares |
| Troluce Capital Advisors LLC | $46,641,756 | 1,728,753 | 1.97% | Shares |
| ANDERA PARTNERS | $42,949,921 | 1,591,917 | 1.82% | Shares |
| SR One Capital Management, LP | $42,195,803 | 1,563,966 | 1.78% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $39,659,818 | 1,469,971 | 1.68% | Shares |
| Pictet Asset Management Holding SA | $38,598,910 | 1,430,649 | 1.63% | Shares |
| Polar Capital Holdings Plc | $38,334,641 | 1,420,854 | 1.62% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $36,657,036 | 1,358,375 | 1.55% | Shares |
| BANK OF AMERICA CORP /DE/ | $36,365,479 | 1,347,868 | 1.54% | Shares |
| MILLENNIUM MANAGEMENT LLC | $32,963,031 | 1,221,758 | 1.39% | Shares |
| GOLDMAN SACHS GROUP INC | $30,925,016 | 1,146,220 | 1.31% | Shares |
| Ghisallo Capital Management LLC | $30,352,500 | 1,125,000 | 1.28% | Shares |
| ALLIANCEBERNSTEIN L.P. | $28,919,686 | 1,067,541 | 1.22% | Shares |
| Logos Global Management LP | $28,329,000 | 1,050,000 | 1.20% | Shares |
| ARMISTICE CAPITAL, LLC | $28,059,200 | 1,040,000 | 1.19% | Call option |
| AMERICAN CENTURY COMPANIES INC | $27,972,049 | 1,036,767 | 1.18% | Shares |
| Davern Capital Partners, LP | $23,169,156 | 858,753 | 0.98% | Shares |
| Candriam S.C.A. | $23,100,611 | 857,037 | 0.98% | Shares |
| Caption Management, LLC | $22,976,168 | 851,600 | 0.97% | Put option |
| Nantahala Capital Management, LLC | $22,136,577 | 820,481 | 0.94% | Shares |
| Affinity Asset Advisors, LLC | $20,235,000 | 750,000 | 0.86% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $20,171,786 | 747,657 | 0.85% | Shares |
| TUDOR INVESTMENT CORP ET AL | $19,921,223 | 738,370 | 0.84% | Shares |
| Aberdeen Group plc | $18,595,560 | 689,235 | 0.79% | Shares |
| ALGERT GLOBAL LLC | $17,510,748 | 649,027 | 0.74% | Shares |
| Catalio Capital Management, LP | $17,502,520 | 648,722 | 0.74% | Shares |
| Pale Fire Capital SE | $16,573,382 | 614,284 | 0.70% | Shares |
| STEMPOINT CAPITAL LP | $16,260,468 | 602,686 | 0.69% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $14,062,408 | 521,216 | 0.59% | Shares |
| VANGUARD GROUP INC | $13,436,227 | 370,246 | 0.57% | Shares |
| Rock Springs Capital Management LP | $13,083,978 | 484,951 | 0.55% | Shares |
| TWO SIGMA ADVISERS, LP | $12,835,773 | 353,700 | 0.54% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $12,468,106 | 462,124 | 0.53% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $12,162,476 | 450,796 | 0.51% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $12,150,983 | 450,370 | 0.51% | Shares |
| Integral Health Asset Management, LLC | $12,141,000 | 450,000 | 0.51% | Shares |
| Prosight Management, LP | $12,135,469 | 449,795 | 0.51% | Shares |
| Rhenman & Partners Asset Management AB | $11,233,690 | 416,371 | 0.48% | Shares |
| Caption Management, LLC | $11,145,087 | 413,087 | 0.47% | Shares |
| JENNISON ASSOCIATES LLC | $10,326,514 | 382,747 | 0.44% | Shares |
| Parkman Healthcare Partners LLC | $10,261,951 | 380,354 | 0.43% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $10,206,534 | 378,300 | 0.43% | Shares |
| CenterBook Partners LP | $9,864,697 | 365,630 | 0.42% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9,593,279 | 355,570 | 0.41% | Shares |
| Iron Triangle Partners LP | $9,329,615 | 257,085 | 0.39% | Shares |
| TimesSquare Capital Management, LLC | $9,178,038 | 338,798 | 0.39% | Shares |
| MORGAN STANLEY | $8,465,685 | 313,776 | 0.36% | Shares |
| Eversept Partners, LP | $8,355,409 | 309,689 | 0.35% | Shares |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $8,251,407 | 306,972 | 0.35% | Shares |
| ADAR1 Capital Management, LLC | $8,063,944 | 298,886 | 0.34% | Shares |
| Longaeva Partners L.P. | $7,584,186 | 281,104 | 0.32% | Shares |
| Qube Research & Technologies Ltd | $6,738,956 | 249,776 | 0.28% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $4,818,628 | 178,600 | 0.20% | Put option |
| MONTANOVA CAPITAL, LLC | $4,691,444 | 173,886 | 0.20% | Shares |
| Trexquant Investment LP | $4,578,911 | 169,715 | 0.19% | Shares |
| TWO SIGMA INVESTMENTS, LP | $4,372,972 | 162,082 | 0.18% | Shares |
| Brevan Howard Capital Management LP | $4,147,420 | 153,722 | 0.18% | Shares |
| Burkehill Global Management, LP | $4,047,000 | 150,000 | 0.17% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $3,976,906 | 147,402 | 0.17% | Shares |
| Caption Management, LLC | $3,879,724 | 143,800 | 0.16% | Call option |
| Artia Global Partners LP | $3,717,844 | 137,800 | 0.16% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3,609,924 | 133,800 | 0.15% | Call option |
| Ensign Peak Advisors, Inc | $3,193,946 | 118,382 | 0.14% | Shares |
| 22NW, LP | $3,071,403 | 113,840 | 0.13% | Shares |
| BlackRock, Inc. | $3,036,896 | 112,561 | 0.13% | Shares |
| Swiss National Bank | $3,010,968 | 111,600 | 0.13% | Shares |
| Ishara Investments LP | $2,765,450 | 102,500 | 0.12% | Shares |
| MARK ASSET MANAGEMENT LP | $2,732,777 | 101,289 | 0.12% | Shares |
| ExodusPoint Capital Management, LP | $2,726,383 | 101,052 | 0.12% | Shares |
| CITIGROUP INC | $2,590,620 | 96,020 | 0.11% | Shares |
| Schonfeld Strategic Advisors LLC | $2,569,628 | 95,242 | 0.11% | Shares |
| ALPS ADVISORS INC | $2,400,572 | 88,976 | 0.10% | Shares |
| CITADEL ADVISORS LLC | $2,349,553 | 87,085 | 0.10% | Shares |
| Squarepoint Ops LLC | $2,329,102 | 86,327 | 0.10% | Shares |
| HighVista Strategies LLC | $2,322,573 | 86,085 | 0.10% | Shares |
| BlueCrest Capital Management Ltd | $2,297,536 | 85,157 | 0.10% | Shares |
| KVP Capital Advisors, LP | $2,270,853 | 84,168 | 0.10% | Shares |
| Rafferty Asset Management, LLC | $2,109,458 | 78,186 | 0.09% | Shares |
| CITADEL ADVISORS LLC | $2,045,084 | 75,800 | 0.09% | Call option |
| STATE OF WISCONSIN INVESTMENT BOARD | $1,976,690 | 73,265 | 0.08% | Shares |
| JANE STREET GROUP, LLC | $1,912,882 | 70,900 | 0.08% | Call option |
| RHUMBLINE ADVISERS | $1,894,120 | 70,205 | 0.08% | Shares |
| JANE STREET GROUP, LLC | $1,702,438 | 63,100 | 0.07% | Put option |
| PFM Health Sciences, LP | $1,684,038 | 62,418 | 0.07% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1,659,696 | 61,266 | 0.07% | Shares |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | $1,598,349 | 59,242 | 0.07% | Shares |
| D. E. Shaw & Co., Inc. | $1,554,075 | 57,601 | 0.07% | Shares |
| DIADEMA PARTNERS LP | $1,520,242 | 56,347 | 0.06% | Shares |
| CITADEL ADVISORS LLC | $1,419,148 | 52,600 | 0.06% | Put option |
| CANADA PENSION PLAN INVESTMENT BOARD | $1,386,772 | 51,400 | 0.06% | Shares |
Company insiders 6 insiders · 2 officers · 2 directors
| Insider | Role | Last activity | Shares owned | Buys 12m | Sells 12m | Net 12m |
|---|---|---|---|---|---|---|
| Jon Congleton | Chief Executive Officer | July 13, 2026 S | 603,621 | 0 | 3 | $-2,251,928 |
| Eric Warren | Chief Commercial Officer | July 21, 2026 M | 38,400 | 0 | 2 | $-2,896,671 |
| Daphne Karydas | Director | June 17, 2026 M | 6,200 | 0 | 1 | $-75,000 |
| HBM Healthcare Investments (Cayman) Ltd. | 10% owner | Feb. 14, 2023 C | 3,218,106 | 0 | 0 | $0 |
| James J. Ferguson III | — | Aug. 10, 2026 A | 102,400 | 0 | 0 | $0 |
| David Malcom Rodman | — | Aug. 10, 2026 M | 51,384 | 0 | 9 | $-1,248,532 |
Insiders from SEC Form 3/4/5 filings; net = open-market P/S only
Activists & 5%+ owners 2 positions
Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.
| Filer | Filed | Stake | Status | Purpose | Filing |
|---|---|---|---|---|---|
| RA Capital Management, L.P., Peter Kolchinsky, Rajeev Shah, RA Capital Healthcare Fund, L.P. ×4 filings | Sept. 8, 2025 | 9.90% | Amendment | — | SEC |
| Samsara BioCapital, L.P., Samsara BioCapital GP, LLC, Samsara Opportunity Fund, L.P., Samsara Opportunity Fund GP, LLC, Srinivas Akkaraju ×4 filings | Sept. 8, 2025 | 8.20% | Amendment | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF ownership Held by 41 ETFs
Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.
| Fund | Weight | Units | As of | Source |
|---|---|---|---|---|
| SBIO · ALPS ETF Trust | 1.59% | 81,578 NS | May 31, 2026 | N-PORT |
| BBC · ETFis Series Trust I | 0.53% | 7,478 NS | April 30, 2026 | N-PORT |
| LABU · Direxion Shares ETF Trust | 0.52% | 101,556 NS | April 30, 2026 | N-PORT |
| ESSC · Strategy Shares | 0.16% | 1,539 NS | April 30, 2026 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0.15% | 4,490 SH | Aug. 8, 2026 | Daily |
| IBB · iShares Trust | 0.13% | 445,700 SH | Aug. 8, 2026 | Daily |
| BIB · ProShares Trust | 0.13% | 2,925 NS | May 31, 2026 | N-PORT |
| IWO · iShares Trust | 0.10% | 521,091 SH | Aug. 8, 2026 | Daily |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0.09% | 61,529 SH | Aug. 8, 2026 | Daily |
| BBSC · J.P. Morgan Exchange-Traded Fund Tr… | 0.07% | 19,142 NS | April 30, 2026 | N-PORT |
| FFSM · FIDELITY COVINGTON TRUST | 0.07% | 33,115 NS | April 30, 2026 | N-PORT |
| SMLF · iShares Trust | 0.06% | 92,257 SH | Aug. 8, 2026 | Daily |
| BKSE · BNY Mellon ETF Trust | 0.06% | 1,696 NS | April 30, 2026 | N-PORT |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.05% | 330,253 SH | Aug. 8, 2026 | Daily |
| IWM · iShares Trust | 0.05% | 1,464,927 SH | Aug. 8, 2026 | Daily |
| ESML · iShares Trust | 0.05% | 51,632 SH | Aug. 8, 2026 | Daily |
| ISCG · iShares Trust | 0.05% | 17,151 SH | Aug. 8, 2026 | Daily |
| VFMO · VANGUARD WELLINGTON FUND | 0.04% | 29,046 SH | Aug. 8, 2026 | Daily |
| RSSL · Global X Funds | 0.04% | 20,663 NS | April 30, 2026 | N-PORT |
| ITWO · ProShares Trust | 0.04% | 2,245 NS | May 31, 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0.04% | 267,668 NS | May 31, 2026 | N-PORT |
| ISCB · iShares Trust | 0.02% | 2,439 SH | Aug. 8, 2026 | Daily |
| UWM · ProShares Trust | 0.02% | 1,757 NS | May 31, 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0.02% | 728,233 SH | Aug. 8, 2026 | Daily |
| VHT · VANGUARD WORLD FUND | 0.02% | 167,502 SH | Aug. 8, 2026 | Daily |
| FHLC · FIDELITY COVINGTON TRUST | 0.02% | 20,978 NS | April 30, 2026 | N-PORT |
| URTY · ProShares Trust | 0.02% | 1,777 NS | May 31, 2026 | N-PORT |
| WSML · iShares Trust | 0.01% | 2,737 SH | Aug. 8, 2026 | Daily |
| DFAS · Dimensional ETF Trust | 0.01% | 49,031 NS | April 30, 2026 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0.01% | 1,918 NS | May 31, 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0.01% | 7,921 SH | Aug. 8, 2026 | Daily |
| HDG · ProShares Trust | 0.01% | 45 NS | May 31, 2026 | N-PORT |
| ONEQ · Fidelity Commonwealth Trust | 0.01% | 22,197 NS | May 31, 2026 | N-PORT |
| ITOT · iShares Trust | 0.00% | 92,521 SH | Aug. 8, 2026 | Daily |
| SCHB · SCHWAB STRATEGIC TRUST | 0.00% | 35,158 NS | May 31, 2026 | N-PORT |
| TILT · FlexShares Trust | 0.00% | 1,540 NS | April 30, 2026 | N-PORT |
| IWV · iShares Trust | 0.00% | 11,075 SH | Aug. 8, 2026 | Daily |
| AVSC · AMERICAN CENTURY ETF TRUST | 0.00% | 466 NS | May 31, 2026 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0.00% | 1,968,124 SH | Aug. 8, 2026 | Daily |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.00% | 4,746 SH | Aug. 8, 2026 | Daily |
| FTLS · First Trust Exchange-Traded Fund III | -0.03% | -28,739 NS | April 30, 2026 | N-PORT |