TSHA — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| Avoro Capital Advisors LLC | $162,683,327 | 23,888,888 | 7.59% | Shares |
| RA CAPITAL MANAGEMENT, L.P. | $160,413,963 | 23,555,648 | 7.48% | Shares |
| GOLDMAN SACHS GROUP INC | $154,676,334 | 22,713,118 | 7.21% | Shares |
| BlackRock, Inc. | $140,912,023 | 20,691,927 | 6.57% | Shares |
| Vestal Point Capital, LP | $132,216,150 | 19,415,000 | 6.17% | Shares |
| MORGAN STANLEY | $112,279,731 | 16,487,479 | 5.24% | Shares |
| RTW INVESTMENTS, LP | $92,345,357 | 13,560,258 | 4.31% | Shares |
| FMR LLC | $90,820,969 | 13,336,413 | 4.24% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $84,979,232 | 12,478,595 | 3.96% | Shares |
| STATE STREET CORP | $77,783,275 | 11,421,920 | 3.63% | Shares |
| VANGUARD GROUP INC | $72,972,929 | 13,267,805 | 3.40% | Shares |
| Siren, L.L.C. | $67,055,203 | 9,846,579 | 3.13% | Shares |
| Octagon Capital Advisors LP | $66,010,992 | 9,693,244 | 3.08% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $44,685,322 | 6,560,394 | 2.08% | Shares |
| Polar Capital Holdings Plc | $34,847,676 | 5,117,133 | 1.63% | Shares |
| MPM BIOIMPACT LLC | $30,645,000 | 4,500,000 | 1.43% | Shares |
| D. E. Shaw & Co., Inc. | $29,954,821 | 4,398,652 | 1.40% | Shares |
| BAKER BROS. ADVISORS LP | $27,272,388 | 4,004,756 | 1.27% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $27,073,870 | 3,975,605 | 1.26% | Shares |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $26,460,262 | 3,885,501 | 1.23% | Shares |
| GordonMD Global Investments LP | $24,501,508 | 723,185 | 1.14% | Shares |
| Casdin Capital, LLC | $22,132,500 | 3,250,000 | 1.03% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $21,383,461 | 3,140,009 | 1.00% | Shares |
| ADAR1 Capital Management, LLC | $20,705,573 | 3,040,466 | 0.97% | Shares |
| Pictet Asset Management Holding SA | $18,868,474 | 2,770,701 | 0.88% | Shares |
| Aberdeen Group plc | $15,847,905 | 2,327,152 | 0.74% | Shares |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | $15,322,500 | 2,250,000 | 0.71% | Shares |
| NORGES BANK | $15,210,816 | 2,233,600 | 0.71% | Shares |
| NORTHERN TRUST CORP | $15,160,491 | 2,226,210 | 0.71% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $14,986,733 | 2,200,695 | 0.70% | Shares |
| MILLENNIUM MANAGEMENT LLC | $14,483,767 | 2,126,838 | 0.68% | Shares |
| ORBIMED ADVISORS LLC | $13,620,000 | 2,000,000 | 0.64% | Shares |
| RICE HALL JAMES & ASSOCIATES, LLC | $13,567,079 | 1,992,229 | 0.63% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $12,914,988 | 1,896,474 | 0.60% | Shares |
| B Group, Inc. | $12,261,786 | 1,800,556 | 0.57% | Shares |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | $12,099,000 | 3,700,000 | 0.56% | Shares |
| Affinity Asset Advisors, LLC | $11,917,500 | 1,750,000 | 0.56% | Shares |
| BARCLAYS PLC | $11,104,787 | 1,630,659 | 0.52% | Shares |
| CITADEL ADVISORS LLC | $10,455,305 | 1,535,287 | 0.49% | Shares |
| HEIGHTS CAPITAL MANAGEMENT, INC | $10,215,000 | 1,500,000 | 0.48% | Shares |
| Seven Fleet Capital Management LP | $9,940,323 | 1,504,400 | 0.46% | Shares |
| Palo Alto Investors LP | $9,475,311 | 1,391,382 | 0.44% | Shares |
| BANK OF AMERICA CORP /DE/ | $9,349,074 | 1,372,845 | 0.44% | Shares |
| Granahan Investment Management, LLC | $8,888,255 | 1,305,177 | 0.41% | Shares |
| Quantum Private Wealth, LLC | $5,529,903 | 812,027 | 0.26% | Shares |
| FIRST TRUST ADVISORS LP | $5,387,860 | 791,169 | 0.25% | Shares |
| JPMORGAN CHASE & CO | $5,157,078 | 766,282 | 0.24% | Shares |
| Sands Capital Alternatives, LLC | $4,936,385 | 724,873 | 0.23% | Shares |
| Bank of New York Mellon Corp | $4,753,180 | 697,971 | 0.22% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $4,358,638 | 640,035 | 0.20% | Shares |
| PANAGORA ASSET MANAGEMENT INC | $4,020,535 | 590,387 | 0.19% | Shares |
| UBS Group AG | $4,007,188 | 588,427 | 0.19% | Shares |
| AFFINITY WEALTH MANAGEMENT LLC | $3,928,062 | 576,808 | 0.18% | Shares |
| Squarepoint Ops LLC | $3,876,722 | 569,269 | 0.18% | Shares |
| ACUTA CAPITAL PARTNERS, LLC | $3,825,912 | 561,808 | 0.18% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3,799,980 | 558,000 | 0.18% | Call option |
| Nuveen, LLC | $3,784,270 | 555,693 | 0.18% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $3,765,930 | 553,000 | 0.18% | Shares |
| DIADEMA PARTNERS LP | $3,559,035 | 522,619 | 0.17% | Shares |
| Woodline Partners LP | $3,499,169 | 513,828 | 0.16% | Shares |
| Holocene Advisors, LP | $3,473,100 | 510,000 | 0.16% | Shares |
| Ghisallo Capital Management LLC | $3,439,050 | 505,000 | 0.16% | Shares |
| Burkehill Global Management, LP | $3,405,000 | 500,000 | 0.16% | Shares |
| POLEN CAPITAL MANAGEMENT LLC | $3,331,581 | 489,219 | 0.16% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $3,162,863 | 464,771 | 0.15% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $2,896,723 | 425,363 | 0.14% | Shares |
| Trexquant Investment LP | $2,584,919 | 379,577 | 0.12% | Shares |
| Swiss National Bank | $2,512,890 | 369,000 | 0.12% | Shares |
| MOORE CAPITAL MANAGEMENT, LP | $2,440,527 | 358,374 | 0.11% | Shares |
| WELLS FARGO & COMPANY/MN | $2,269,869 | 333,314 | 0.11% | Shares |
| Jefferies Financial Group Inc. | $2,239,128 | 328,800 | 0.10% | Shares |
| CITIGROUP INC | $2,090,037 | 306,907 | 0.10% | Shares |
| RHUMBLINE ADVISERS | $2,042,820 | 299,975 | 0.10% | Shares |
| ALPS ADVISORS INC | $1,978,598 | 290,543 | 0.09% | Shares |
| Invesco Ltd. | $1,800,421 | 264,379 | 0.08% | Shares |
| Ensign Peak Advisors, Inc | $1,790,322 | 262,896 | 0.08% | Shares |
| Qube Research & Technologies Ltd | $1,767,910 | 259,605 | 0.08% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $1,702,500 | 250,000 | 0.08% | Shares |
| DEUTSCHE BANK AG\ | $1,657,411 | 243,379 | 0.08% | Shares |
| TWO SIGMA INVESTMENTS, LP | $1,598,416 | 234,716 | 0.07% | Shares |
| JANE STREET GROUP, LLC | $1,555,098 | 228,355 | 0.07% | Shares |
| ORACLE INVESTMENT MANAGEMENT INC | $1,457,500 | 265,000 | 0.07% | Shares |
| Monashee Investment Management LLC | $1,362,000 | 200,000 | 0.06% | Shares |
| Privium Fund Management B.V. | $1,354,509 | 198,900 | 0.06% | Shares |
| VICTORY CAPITAL MANAGEMENT INC | $1,345,506 | 197,578 | 0.06% | Shares |
| Chicago Partners Investment Group LLC | $1,296,283 | 222,347 | 0.06% | Shares |
| Balyasny Asset Management L.P. | $1,289,351 | 189,332 | 0.06% | Shares |
| STATE OF WISCONSIN INVESTMENT BOARD | $1,205,976 | 177,089 | 0.06% | Shares |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1,188,104 | 265,795 | 0.06% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1,153,437 | 169,374 | 0.05% | Shares |
| RAYMOND JAMES FINANCIAL INC | $1,130,746 | 166,042 | 0.05% | Shares |
| ALLIANCEBERNSTEIN L.P. | $1,107,130 | 247,680 | 0.05% | Shares |
| WEXFORD CAPITAL LP | $1,094,054 | 160,654 | 0.05% | Shares |
| Rafferty Asset Management, LLC | $1,053,548 | 154,706 | 0.05% | Shares |
| Palumbo Wealth Management LLC | $1,015,869 | 149,173 | 0.05% | Shares |
| MetLife Investment Management, LLC | $959,161 | 140,846 | 0.04% | Shares |
| Vanguard Global Advisers, LLC | $911,321 | 133,821 | 0.04% | Shares |
| Persistent Asset Partners Ltd | $908,529 | 133,411 | 0.04% | Shares |
| VANGUARD ASSET MANAGEMENT, Ltd | $903,101 | 132,614 | 0.04% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $876,883 | 128,764 | 0.04% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $869,664 | 127,915 | 0.04% | Shares |
| Mariner, LLC | $793,923 | 116,582 | 0.04% | Shares |
| CITADEL ADVISORS LLC | $783,150 | 115,000 | 0.04% | Call option |
| TWO SIGMA ADVISERS, LP | $767,696 | 139,581 | 0.04% | Shares |
| Aquatic Capital Management LLC | $736,896 | 108,208 | 0.03% | Shares |
| Legal & General Group Plc | $736,890 | 108,207 | 0.03% | Shares |
| FRANKLIN RESOURCES INC | $723,835 | 106,290 | 0.03% | Shares |
| Engineers Gate Manager LP | $709,139 | 104,132 | 0.03% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $708,887 | 104,095 | 0.03% | Shares |
| XTX Topco Ltd | $689,138 | 101,195 | 0.03% | Shares |
| PRELUDE CAPITAL MANAGEMENT, LLC | $669,736 | 98,346 | 0.03% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $663,294 | 97,400 | 0.03% | Put option |
| PROFUND ADVISORS LLC | $546,162 | 80,200 | 0.03% | Shares |
| Police & Firemen's Retirement System of New Jersey | $481,596 | 70,719 | 0.02% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $471,933 | 69,300 | 0.02% | Shares |
| J. Goldman & Co LP | $458,647 | 67,349 | 0.02% | Shares |
| RED REEF ADVISORS LLC | $449,120 | 65,950 | 0.02% | Shares |
| China Universal Asset Management Co., Ltd. | $447,649 | 65,734 | 0.02% | Shares |
| Creative Planning | $434,349 | 63,781 | 0.02% | Shares |
| CITADEL ADVISORS LLC | $428,349 | 62,900 | 0.02% | Put option |
| COMMONWEALTH EQUITY SERVICES, LLC | $420,678 | 61,773 | 0.02% | Shares |
| Russell Investments Group, Ltd. | $420,210 | 61,705 | 0.02% | Shares |
| OMERS ADMINISTRATION Corp | $402,471 | 59,100 | 0.02% | Shares |
| Virtus Investment Advisers, LLC | $390,233 | 57,303 | 0.02% | Shares |
| LANARK FINANCIAL, INC. | $374,699 | 55,022 | 0.02% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $358,329 | 52,618 | 0.02% | Shares |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $335,141 | 49,213 | 0.02% | Shares |
| KLP KAPITALFORVALTNING AS | $325,518 | 47,800 | 0.02% | Shares |
| Militia Capital Management LLC | $316,665 | 46,500 | 0.01% | Shares |
| State of New Jersey Common Pension Fund D | $316,277 | 46,443 | 0.01% | Shares |
| JANUS HENDERSON GROUP PLC | $308,085 | 69,000 | 0.01% | Shares |
| Williams & Novak, LLC | $306,450 | 45,000 | 0.01% | Shares |
| Almanack Investment Partners, LLC. | $306,110 | 44,950 | 0.01% | Shares |
| FIRST MANHATTAN CO. LLC. | $296,235 | 43,500 | 0.01% | Shares |
| Mitsubishi UFJ Asset Management Co., Ltd. | $294,131 | 43,191 | 0.01% | Shares |
| Allianz Asset Management GmbH | $288,744 | 42,400 | 0.01% | Shares |
| ProShare Advisors LLC | $277,965 | 40,817 | 0.01% | Shares |
| ARIZONA STATE RETIREMENT SYSTEM | $269,901 | 39,633 | 0.01% | Shares |
| PRUDENTIAL FINANCIAL INC | $265,862 | 39,040 | 0.01% | Shares |
| JANE STREET GROUP, LLC | $260,142 | 38,200 | 0.01% | Call option |
| Militia Capital Partners, LP | $255,750 | 46,500 | 0.01% | Shares |
| ENVESTNET ASSET MANAGEMENT INC | $254,108 | 37,314 | 0.01% | Shares |
| Vanguard Investments Australia, Ltd. | $244,390 | 35,887 | 0.01% | Shares |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $218,935 | 32,149 | 0.01% | Shares |
| Cetera Investment Advisers | $215,244 | 31,607 | 0.01% | Shares |
| GUGGENHEIM CAPITAL LLC | $202,401 | 29,721 | 0.01% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $184,987 | 27,164 | 0.01% | Shares |
| Quadrature Capital Ltd | $175,378 | 25,753 | 0.01% | Shares |
| nVerses Capital, LLC | $171,285 | 25,152 | 0.01% | Shares |
| State of Wyoming | $166,041 | 24,382 | 0.01% | Shares |
| XPONANCE LLC | $155,820 | 22,881 | 0.01% | Shares |
| E Fund Management Co., Ltd. | $148,553 | 21,814 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $148,192 | 21,761 | 0.01% | Shares |
| Lee Financial Co | $136,200 | 20,000 | 0.01% | Shares |
| ALLSTATE CORP | $132,434 | 19,447 | 0.01% | Shares |
| Weiss Asset Management LP | $130,371 | 19,144 | 0.01% | Shares |
| Aster Capital Management (DIFC) Ltd | $126,346 | 18,553 | 0.01% | Shares |
| PRINCIPAL FINANCIAL GROUP INC | $124,855 | 18,334 | 0.01% | Shares |
| Vanguard Personalized Indexing Management, LLC | $122,437 | 17,979 | 0.01% | Shares |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $113,972 | 16,736 | 0.01% | Shares |
| ST GERMAIN D J CO INC | $96,246 | 14,133 | 0.00% | Shares |
| SEI INVESTMENTS CO | $95,004 | 13,952 | 0.00% | Shares |
| BANK OF MONTREAL /CAN/ | $93,079 | 13,668 | 0.00% | Shares |
| CAPTRUST FINANCIAL ADVISORS | $91,629 | 13,455 | 0.00% | Shares |
| SIMPLEX TRADING, LLC | $91,056 | 13,371 | 0.00% | Shares |
| CIBC Bancorp USA Inc. | $90,315 | 13,262 | 0.00% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $87,522 | 12,852 | 0.00% | Shares |
| Ethic Inc. | $85,207 | 12,512 | 0.00% | Shares |
| CIBC WORLD MARKETS CORP | $80,366 | 14,612 | 0.00% | Shares |
| Tower Research Capital LLC (TRC) | $78,519 | 11,530 | 0.00% | Shares |
| Magnetar Financial LLC | $78,145 | 11,475 | 0.00% | Shares |
| NEUBERGER BERMAN GROUP LLC | $76,068 | 11,170 | 0.00% | Shares |
| Summit Financial, LLC | $74,147 | 10,888 | 0.00% | Shares |
| CHOREO, LLC | $72,309 | 10,618 | 0.00% | Shares |
| Capital Investment Advisors, LLC | $68,100 | 10,000 | 0.00% | Shares |
| OSAIC HOLDINGS, INC. | $60,191 | 8,838 | 0.00% | Shares |
| CWM, LLC | $58,472 | 13,081 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $51,000 | 7,386 | 0.00% | Shares |
| Allworth Financial LP | $47,521 | 6,978 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $39,478 | 5,797 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $39,362 | 5,780 | 0.00% | Shares |
| Rockefeller Capital Management L.P. | $34,050 | 5,000 | 0.00% | Shares |
| Bordeaux Wealth Advisors LLC | $23,234 | 10,058 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $20,873 | 3,065 | 0.00% | Shares |
| Steward Partners Investment Advisory, LLC | $20,430 | 3,000 | 0.00% | Shares |
| Kemnay Advisory Services Inc. | $17,583 | 2,582 | 0.00% | Shares |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $14,294 | 2,099 | 0.00% | Shares |
| Chung Wu Investment Group, LLC | $13,620 | 2,000 | 0.00% | Shares |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | $13,300 | 2,000 | 0.00% | Shares |
| GROUP ONE TRADING LLC | $13,205 | 1,939 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $12,633 | 1,855 | 0.00% | Shares |
| JONES FINANCIAL COMPANIES LLLP | $9,263 | 1,461 | 0.00% | Shares |
| US BANCORP \DE\ | $7,845 | 1,152 | 0.00% | Shares |
| PNC Financial Services Group, Inc. | $7,171 | 1,053 | 0.00% | Shares |
| Sterling Capital Management LLC | $5,734 | 842 | 0.00% | Shares |
| Federation des caisses Desjardins du Quebec | $3,405 | 500 | 0.00% | Shares |
| Quarry LP | $3,269 | 480 | 0.00% | Shares |
| Larson Financial Group LLC | $3,194 | 469 | 0.00% | Shares |
| Optiver Holding B.V. | $3,017 | 443 | 0.00% | Shares |
| Arax Advisory Partners | $2,451 | 360 | 0.00% | Shares |
| Essential Partners LLC | $2,227 | 327 | 0.00% | Shares |
| Parallel Advisors, LLC | $1,907 | 280 | 0.00% | Shares |
| SIGNATUREFD, LLC | $1,811 | 266 | 0.00% | Shares |
| GAMMA Investing LLC | $1,580 | 232 | 0.00% | Shares |
| SG Americas Securities, LLC | $1,377 | 202,260 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1,359 | 199,494 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $1,158 | 170 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $960 | 141 | 0.00% | Shares |
| Lindbrook Capital, LLC | $605 | 435 | 0.00% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $578 | 85 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $494 | 72,573 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $375 | 55 | 0.00% | Shares |
| True Wealth Design, LLC | $205 | 30 | 0.00% | Shares |
| Keating Financial Advisory Services, Inc. | $177 | 26 | 0.00% | Shares |
| Cambridge Investment Research Advisors, Inc. | $103 | 15,075 | 0.00% | Shares |
| Thrivent Financial for Lutherans | $98 | 14,520 | 0.00% | Shares |
| IFP Advisors, Inc | $95 | 14 | 0.00% | Shares |
| Hughes Financial Services, LLC | $41 | 6 | 0.00% | Shares |
| Pacer Advisors, Inc. | $18 | 2,584 | 0.00% | Shares |
| Covestor Ltd | $1 | 94 | 0.00% | Shares |
| Capital Advisors, Ltd. LLC | $1 | 79 | 0.00% | Shares |