AKTS — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| MPM BIOIMPACT LLC | $155,860,155 | 4,835,872 | 15.71% | Shares |
| EcoR1 Capital, LLC | $155,492,636 | 4,824,469 | 15.67% | Shares |
| Blue Owl Capital Holdings LP | $98,953,158 | 3,070,219 | 9.97% | Shares |
| BlackRock, Inc. | $73,431,479 | 2,278,358 | 7.40% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $63,372,044 | 1,966,244 | 6.39% | Shares |
| RTW INVESTMENTS, LP | $51,311,546 | 1,592,043 | 5.17% | Shares |
| RA CAPITAL MANAGEMENT, L.P. | $42,363,273 | 1,314,405 | 4.27% | Shares |
| BAKER BROS. ADVISORS LP | $32,112,393 | 996,351 | 3.24% | Shares |
| Octagon Capital Advisors LP | $30,968,099 | 960,847 | 3.12% | Shares |
| Merck & Co., Inc. | $30,710,162 | 952,844 | 3.09% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $26,334,327 | 817,075 | 2.65% | Shares |
| JANUS HENDERSON GROUP PLC | $26,022,437 | 1,454,267 | 2.62% | Shares |
| TCG Crossover Management, LLC | $22,450,129 | 696,560 | 2.26% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $16,787,478 | 520,737 | 1.69% | Shares |
| EVENTIDE ASSET MANAGEMENT, LLC | $16,340,610 | 507,000 | 1.65% | Shares |
| Avidity Partners Management LP | $15,605,766 | 484,200 | 1.57% | Shares |
| STATE STREET CORP | $15,599,642 | 484,010 | 1.57% | Shares |
| a16z Capital Management, L.L.C. | $13,375,450 | 415,000 | 1.35% | Shares |
| Alyeska Investment Group, L.P. | $9,346,700 | 290,000 | 0.94% | Shares |
| FMR LLC | $9,205,887 | 285,631 | 0.93% | Shares |
| ArrowMark Colorado Holdings LLC | $7,924,455 | 245,872 | 0.80% | Shares |
| NORTHERN TRUST CORP | $5,819,933 | 180,575 | 0.59% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $5,377,318 | 166,842 | 0.54% | Shares |
| BARCLAYS PLC | $4,889,163 | 151,696 | 0.49% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $4,680,441 | 145,220 | 0.47% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $4,313,470 | 133,834 | 0.43% | Shares |
| TD Asset Management Inc | $3,413,221 | 105,902 | 0.34% | Shares |
| SOROS FUND MANAGEMENT LLC | $3,223,000 | 100,000 | 0.32% | Shares |
| Woodline Partners LP | $3,223,000 | 100,000 | 0.32% | Shares |
| UBS Group AG | $3,221,711 | 99,960 | 0.32% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $3,074,742 | 95,400 | 0.31% | Shares |
| BANK OF AMERICA CORP /DE/ | $2,347,472 | 72,835 | 0.24% | Shares |
| POLEN CAPITAL MANAGEMENT LLC | $2,047,056 | 63,514 | 0.21% | Shares |
| MORGAN STANLEY | $2,018,758 | 62,636 | 0.20% | Shares |
| RAYMOND JAMES FINANCIAL INC | $1,626,455 | 50,464 | 0.16% | Shares |
| Nuveen, LLC | $1,605,569 | 49,816 | 0.16% | Shares |
| Bank of New York Mellon Corp | $1,587,324 | 49,250 | 0.16% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $1,551,005 | 48,123 | 0.16% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1,548,458 | 48,044 | 0.16% | Shares |
| Quantinno Capital Management LP | $1,511,168 | 46,887 | 0.15% | Shares |
| GREAT LAKES ADVISORS, LLC | $1,405,615 | 43,612 | 0.14% | Shares |
| Mirador Capital Partners LP | $1,293,197 | 40,124 | 0.13% | Shares |
| Squarepoint Ops LLC | $1,237,020 | 38,381 | 0.12% | Shares |
| Jump Financial, LLC | $1,056,467 | 32,779 | 0.11% | Shares |
| Sofinnova Investments, Inc. | $1,045,412 | 32,436 | 0.11% | Shares |
| TWO SIGMA INVESTMENTS, LP | $996,358 | 30,914 | 0.10% | Shares |
| READYSTATE ASSET MANAGEMENT LP | $966,900 | 30,000 | 0.10% | Shares |
| WELLS FARGO & COMPANY/MN | $891,450 | 27,659 | 0.09% | Shares |
| RHUMBLINE ADVISERS | $868,429 | 26,945 | 0.09% | Shares |
| CITADEL ADVISORS LLC | $823,058 | 25,537 | 0.08% | Shares |
| SEVEN GRAND MANAGERS, LLC | $805,750 | 25,000 | 0.08% | Shares |
| Ghisallo Capital Management LLC | $805,750 | 25,000 | 0.08% | Shares |
| TUDOR INVESTMENT CORP ET AL | $689,786 | 21,402 | 0.07% | Shares |
| GOLDMAN SACHS GROUP INC | $685,790 | 21,278 | 0.07% | Shares |
| DEUTSCHE BANK AG\ | $677,539 | 21,022 | 0.07% | Shares |
| AMERIPRISE FINANCIAL INC | $644,600 | 20,000 | 0.06% | Shares |
| Mariner, LLC | $572,697 | 17,770 | 0.06% | Shares |
| SEI INVESTMENTS CO | $528,515 | 16,402 | 0.05% | Shares |
| Virtus Investment Advisers, LLC | $480,872 | 14,920 | 0.05% | Shares |
| Invesco Ltd. | $480,485 | 14,908 | 0.05% | Shares |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $463,435 | 14,379 | 0.05% | Shares |
| CITIGROUP INC | $424,695 | 13,177 | 0.04% | Shares |
| MetLife Investment Management, LLC | $418,797 | 12,994 | 0.04% | Shares |
| Caprock Group, LLC | $319,335 | 9,908 | 0.03% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $314,855 | 9,769 | 0.03% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $277,919 | 8,623 | 0.03% | Shares |
| JPMORGAN CHASE & CO | $266,021 | 8,835 | 0.03% | Shares |
| Russell Investments Group, Ltd. | $249,911 | 7,754 | 0.03% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $241,725 | 7,500 | 0.02% | Shares |
| AXQ CAPITAL, LP | $226,255 | 7,020 | 0.02% | Shares |
| Vanguard Global Advisers, LLC | $221,936 | 6,886 | 0.02% | Shares |
| PNC Financial Services Group, Inc. | $197,893 | 6,140 | 0.02% | Shares |
| Police & Firemen's Retirement System of New Jersey | $178,232 | 5,530 | 0.02% | Shares |
| LANARK FINANCIAL, INC. | $172,688 | 5,358 | 0.02% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $105,714 | 3,280 | 0.01% | Shares |
| STRS OHIO | $99,913 | 3,100 | 0.01% | Shares |
| Tower Research Capital LLC (TRC) | $73,098 | 2,268 | 0.01% | Shares |
| Pinnacle Wealth Planning Services, Inc. | $73,065 | 2,267 | 0.01% | Shares |
| Legal & General Group Plc | $66,623 | 2,062 | 0.01% | Shares |
| T. Rowe Price Investment Management, Inc. | $66,119 | 2,051,447 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $62,043 | 1,925 | 0.01% | Shares |
| SALEM INVESTMENT COUNSELORS INC | $32,230 | 1,000 | 0.00% | Shares |
| State of Wyoming | $31,747 | 985 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $25,000 | 797 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $24,608 | 763,499 | 0.00% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $22,589 | 700 | 0.00% | Shares |
| FIFTH THIRD BANCORP | $18,576 | 576 | 0.00% | Shares |
| Rockefeller Capital Management L.P. | $12,795 | 397 | 0.00% | Shares |
| Global Retirement Partners, LLC | $12,731 | 395 | 0.00% | Shares |
| Arax Advisory Partners | $12,408 | 385 | 0.00% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $9,282 | 288 | 0.00% | Shares |
| Federation des caisses Desjardins du Quebec | $8,057 | 250 | 0.00% | Shares |
| Versant Capital Management, Inc | $6,308 | 324 | 0.00% | Shares |
| Sterling Capital Management LLC | $5,930 | 184 | 0.00% | Shares |
| Allworth Financial LP | $3,997 | 124 | 0.00% | Shares |
| IFP Advisors, Inc | $3,255 | 101 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $2,578 | 80 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $2,414 | 77 | 0.00% | Shares |
| HM PAYSON & CO | $2,386 | 74 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $1,257 | 39 | 0.00% | Shares |
| Quarry LP | $1,096 | 34 | 0.00% | Shares |
| SJS Investment Consulting Inc. | $1,064 | 33 | 0.00% | Shares |
| CoreCap Advisors, LLC | $935 | 29 | 0.00% | Shares |
| WPG Advisers, LLC | $806 | 25 | 0.00% | Shares |
| FWL INVESTMENT MANAGEMENT, LLC | $741 | 23 | 0.00% | Shares |
| GAMMA Investing LLC | $645 | 20 | 0.00% | Shares |
| Rossby Financial, LCC | $580 | 18 | 0.00% | Shares |
| CWM, LLC | $376 | 21 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $258 | 8 | 0.00% | Shares |
| Clearstead Advisors, LLC | $195 | 6 | 0.00% | Shares |
| Essential Partners LLC | $129 | 4 | 0.00% | Shares |
| SG Americas Securities, LLC | $109 | 3,368 | 0.00% | Shares |
| Freestone Grove Partners LP | $64 | 2 | 0.00% | Shares |
| Covestor Ltd | $1 | 23 | 0.00% | Shares |