DSGN — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| SR One Capital Management, LP | $94,438,108 | 6,526,476 | 14.39% | Shares |
| Logos Global Management LP | $43,410,000 | 3,000,000 | 6.62% | Shares |
| BAKER BROS. ADVISORS LP | $38,756,882 | 2,678,430 | 5.91% | Shares |
| Driehaus Capital Management LLC | $38,506,334 | 2,661,115 | 5.87% | Shares |
| BlackRock, Inc. | $38,490,551 | 2,660,024 | 5.87% | Shares |
| Point72 Asset Management, L.P. | $34,242,575 | 2,366,453 | 5.22% | Shares |
| Trails Edge Capital Partners, LP | $28,958,550 | 2,001,282 | 4.41% | Shares |
| Frazier Life Sciences Management, L.P. | $26,188,587 | 1,809,854 | 3.99% | Shares |
| Vivo Capital, LLC | $23,338,706 | 1,612,903 | 3.56% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $22,732,688 | 1,571,022 | 3.46% | Shares |
| Caption Management, LLC | $21,705,000 | 1,500,000 | 3.31% | Call option |
| Caption Management, LLC | $16,178,878 | 1,118,098 | 2.47% | Shares |
| VANGUARD GROUP INC | $15,297,936 | 1,630,910 | 2.33% | Shares |
| Almitas Capital LLC | $14,859,142 | 1,026,893 | 2.26% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $13,871,597 | 958,417 | 2.11% | Shares |
| Sofinnova Investments, Inc. | $12,518,503 | 865,135 | 1.91% | Shares |
| FMR LLC | $11,235,405 | 776,462 | 1.71% | Shares |
| MORGAN STANLEY | $11,075,699 | 765,425 | 1.69% | Shares |
| STATE STREET CORP | $10,653,118 | 736,221 | 1.62% | Shares |
| Woodline Partners LP | $10,134,122 | 700,354 | 1.54% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $10,051,800 | 694,743 | 1.53% | Shares |
| GOLDMAN SACHS GROUP INC | $9,500,771 | 656,584 | 1.45% | Shares |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $8,184,189 | 565,597 | 1.25% | Shares |
| Siren, L.L.C. | $7,570,878 | 523,212 | 1.15% | Shares |
| Qube Research & Technologies Ltd | $6,324,533 | 437,079 | 0.96% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $5,613,101 | 387,913 | 0.86% | Shares |
| KENNEDY CAPITAL MANAGEMENT LLC | $5,557,001 | 384,036 | 0.85% | Shares |
| NORTHERN TRUST CORP | $5,110,762 | 353,197 | 0.78% | Shares |
| ALGERT GLOBAL LLC | $4,284,350 | 296,085 | 0.65% | Shares |
| ACUTA CAPITAL PARTNERS, LLC | $4,088,701 | 282,564 | 0.62% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $3,925,190 | 271,264 | 0.60% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $3,638,366 | 251,442 | 0.55% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $3,331,023 | 230,202 | 0.51% | Shares |
| PRUDENTIAL FINANCIAL INC | $3,243,740 | 224,170 | 0.49% | Shares |
| D. E. Shaw & Co., Inc. | $2,830,983 | 195,645 | 0.43% | Shares |
| Eversept Partners, LP | $2,749,300 | 190,000 | 0.42% | Shares |
| KVP Capital Advisors, LP | $2,676,950 | 185,000 | 0.41% | Shares |
| J. Goldman & Co LP | $2,557,862 | 176,770 | 0.39% | Shares |
| MILLENNIUM MANAGEMENT LLC | $2,137,422 | 147,714 | 0.33% | Shares |
| RAYMOND JAMES FINANCIAL INC | $2,004,399 | 138,521 | 0.31% | Shares |
| Balyasny Asset Management L.P. | $1,607,660 | 111,103 | 0.25% | Shares |
| Elmind Capital, LP | $1,561,313 | 107,900 | 0.24% | Shares |
| Nuveen, LLC | $1,515,501 | 104,734 | 0.23% | Shares |
| DAFNA Capital Management LLC | $1,484,622 | 102,600 | 0.23% | Shares |
| Bank of New York Mellon Corp | $1,332,238 | 92,069 | 0.20% | Shares |
| China Universal Asset Management Co., Ltd. | $1,301,432 | 89,940 | 0.20% | Shares |
| CITADEL ADVISORS LLC | $1,186,120 | 81,971 | 0.18% | Shares |
| SummitTX Capital, L.P. | $1,167,194 | 80,663 | 0.18% | Shares |
| AMERICAN CENTURY COMPANIES INC | $1,111,658 | 76,825 | 0.17% | Shares |
| Palumbo Wealth Management LLC | $1,038,136 | 71,744 | 0.16% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $1,029,019 | 71,114 | 0.16% | Shares |
| AMERIPRISE FINANCIAL INC | $978,143 | 67,598 | 0.15% | Shares |
| Russell Investments Group, Ltd. | $967,448 | 66,859 | 0.15% | Shares |
| ALPS ADVISORS INC | $917,268 | 63,391 | 0.14% | Shares |
| STATE OF WISCONSIN INVESTMENT BOARD | $857,333 | 59,249 | 0.13% | Shares |
| STRS OHIO | $730,735 | 50,500 | 0.11% | Shares |
| Verdad Advisers, LP | $688,150 | 47,557 | 0.10% | Shares |
| BANK OF AMERICA CORP /DE/ | $632,745 | 43,728 | 0.10% | Shares |
| ExodusPoint Capital Management, LP | $597,408 | 41,286 | 0.09% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $578,800 | 40,000 | 0.09% | Call option |
| RHUMBLINE ADVISERS | $551,760 | 38,132 | 0.08% | Shares |
| Vanguard Global Advisers, LLC | $514,177 | 35,534 | 0.08% | Shares |
| UBS Group AG | $502,992 | 34,761 | 0.08% | Shares |
| Susquehanna Portfolio Strategies, LLC | $482,936 | 33,375 | 0.07% | Shares |
| TWO SIGMA INVESTMENTS, LP | $476,425 | 32,925 | 0.07% | Shares |
| CANADA PENSION PLAN INVESTMENT BOARD | $471,722 | 32,600 | 0.07% | Shares |
| OPPENHEIMER & CO INC | $464,299 | 32,087 | 0.07% | Shares |
| ALLIANCEBERNSTEIN L.P. | $459,967 | 43,230 | 0.07% | Shares |
| DEUTSCHE BANK AG\ | $442,970 | 30,613 | 0.07% | Shares |
| Virtus Investment Advisers, LLC | $431,597 | 29,827 | 0.07% | Shares |
| Squarepoint Ops LLC | $428,746 | 29,630 | 0.07% | Shares |
| Trexquant Investment LP | $407,331 | 28,150 | 0.06% | Shares |
| WELLS FARGO & COMPANY/MN | $406,202 | 28,072 | 0.06% | Shares |
| Corient Private Wealth LP | $393,136 | 27,169 | 0.06% | Shares |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $390,690 | 27,000 | 0.06% | Shares |
| Quantinno Capital Management LP | $389,257 | 26,901 | 0.06% | Shares |
| SEI INVESTMENTS CO | $329,053 | 22,740 | 0.05% | Shares |
| XTX Topco Ltd | $323,882 | 22,383 | 0.05% | Shares |
| AlphaCentric Advisors LLC | $311,640 | 21,537 | 0.05% | Shares |
| Invesco Ltd. | $310,078 | 21,429 | 0.05% | Shares |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $299,529 | 20,700 | 0.05% | Shares |
| MetLife Investment Management, LLC | $298,212 | 20,609 | 0.05% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $280,718 | 19,400 | 0.04% | Shares |
| JPMORGAN CHASE & CO | $240,713 | 16,904 | 0.04% | Shares |
| TWO SIGMA ADVISERS, LP | $237,314 | 25,300 | 0.04% | Shares |
| CITIGROUP INC | $229,784 | 15,880 | 0.04% | Shares |
| Creative Planning | $229,263 | 15,844 | 0.03% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $226,456 | 15,650 | 0.03% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $214,503 | 14,824 | 0.03% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $205,054 | 14,171 | 0.03% | Shares |
| CITADEL ADVISORS LLC | $201,133 | 13,900 | 0.03% | Call option |
| Y-Intercept (Hong Kong) Ltd | $186,808 | 12,910 | 0.03% | Shares |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $181,642 | 12,553 | 0.03% | Shares |
| ROYAL BANK OF CANADA | $178,000 | 12,254 | 0.03% | Shares |
| BARCLAYS PLC | $169,401 | 11,707 | 0.03% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $156,652 | 10,826 | 0.02% | Shares |
| Police & Firemen's Retirement System of New Jersey | $142,515 | 9,849 | 0.02% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $83,217 | 5,751 | 0.01% | Shares |
| Clearstead Advisors, LLC | $81,177 | 5,610 | 0.01% | Shares |
| Tower Research Capital LLC (TRC) | $71,019 | 4,908 | 0.01% | Shares |
| Rockefeller Capital Management L.P. | $53,308 | 3,684 | 0.01% | Shares |
| CAZ INVESTMENTS LP | $50,645 | 3,500 | 0.01% | Shares |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $43,772 | 3,025 | 0.01% | Shares |
| Legal & General Group Plc | $43,222 | 2,987 | 0.01% | Shares |
| Point72 Asia (Singapore) Pte. Ltd. | $42,940 | 5,702 | 0.01% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $40,415 | 2,793 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $40,415 | 2,793 | 0.01% | Shares |
| State of Wyoming | $37,130 | 2,566 | 0.01% | Shares |
| PNC Financial Services Group, Inc. | $26,277 | 1,816 | 0.00% | Shares |
| GAMMA Investing LLC | $20,982 | 1,450 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $18,218 | 1,259 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $17,494 | 1,209 | 0.00% | Shares |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $12,162 | 1,143 | 0.00% | Shares |
| ACADIAN ASSET MANAGEMENT LLC | $7,774 | 537,479 | 0.00% | Shares |
| Private Wealth Management Group, LLC | $7,713 | 533 | 0.00% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $4,847 | 335 | 0.00% | Shares |
| CWM, LLC | $4,501 | 423 | 0.00% | Shares |
| Physician Wealth Advisors, Inc. | $3,878 | 268 | 0.00% | Shares |
| MassMutual Private Wealth & Trust, FSB | $3,458 | 239 | 0.00% | Shares |
| Stone House Investment Management, LLC | $3,458 | 239 | 0.00% | Shares |
| OSAIC HOLDINGS, INC. | $3,255 | 225 | 0.00% | Shares |
| Larson Financial Group LLC | $2,619 | 181 | 0.00% | Shares |
| Arax Advisory Partners | $2,606 | 180 | 0.00% | Shares |
| SIMPLEX TRADING, LLC | $2,488 | 172 | 0.00% | Shares |
| Optiver Holding B.V. | $2,315 | 160 | 0.00% | Shares |
| Sterling Capital Management LLC | $1,563 | 108 | 0.00% | Shares |
| Allworth Financial LP | $1,390 | 96 | 0.00% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $1,199 | 83 | 0.00% | Shares |
| Versant Capital Management, Inc | $1,081 | 86 | 0.00% | Shares |
| Silver Grove Financial Group, Inc. | $839 | 58 | 0.00% | Shares |
| Quarry LP | $449 | 31 | 0.00% | Shares |
| US BANCORP \DE\ | $376 | 26 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $371 | 25,606 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $362 | 25 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $318 | 22 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $289 | 20 | 0.00% | Shares |
| True Wealth Design, LLC | $261 | 18 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $149 | 10,328 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $145 | 10 | 0.00% | Shares |
| SJS Investment Consulting Inc. | $58 | 4 | 0.00% | Shares |
| Essential Partners LLC | $14 | 1 | 0.00% | Shares |
| Capital Advisors, Ltd. LLC | $0 | 12 | 0.00% | Shares |