ACRS — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $67,304,808 | 12,723,026 | 10.40% | Shares |
| BML Capital Management, LLC | $63,347,750 | 11,975,000 | 9.79% | Shares |
| BlackRock, Inc. | $53,095,772 | 10,037,008 | 8.21% | Shares |
| Deep Track Capital, LP | $49,435,050 | 9,345,000 | 7.64% | Shares |
| Vivo Capital, LLC | $35,414,630 | 6,694,637 | 5.47% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $30,776,511 | 5,817,866 | 4.76% | Shares |
| Frazier Life Sciences Management, L.P. | $26,055,228 | 4,925,374 | 4.03% | Shares |
| Rock Springs Capital Management LP | $22,908,514 | 4,330,532 | 3.54% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $21,535,590 | 4,071,000 | 3.33% | Shares |
| Decheng Capital LLC | $21,380,783 | 4,041,736 | 3.30% | Shares |
| VANGUARD GROUP INC | $19,571,260 | 6,502,080 | 3.02% | Shares |
| STATE STREET CORP | $17,220,749 | 3,255,340 | 2.66% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $16,879,468 | 3,190,058 | 2.61% | Shares |
| BRAIDWELL LP | $11,333,021 | 2,142,348 | 1.75% | Shares |
| Balyasny Asset Management L.P. | $10,704,156 | 2,023,470 | 1.65% | Shares |
| SILVERARC CAPITAL MANAGEMENT, LLC | $10,296,890 | 1,946,482 | 1.59% | Shares |
| Kalehua Capital Management LLC | $9,693,211 | 1,832,365 | 1.50% | Shares |
| CITADEL ADVISORS LLC | $9,321,408 | 1,762,081 | 1.44% | Shares |
| Jones Hill Capital LP | $9,307,713 | 1,759,492 | 1.44% | Shares |
| Palo Alto Investors LP | $8,535,045 | 1,613,430 | 1.32% | Shares |
| Woodline Partners LP | $8,522,476 | 1,611,054 | 1.32% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $7,753,738 | 1,465,735 | 1.20% | Shares |
| PANAGORA ASSET MANAGEMENT INC | $7,174,044 | 1,356,152 | 1.11% | Shares |
| Connor, Clark & Lunn Investment Management Ltd. | $6,400,297 | 1,209,886 | 0.99% | Shares |
| MPM BIOIMPACT LLC | $5,514,650 | 1,042,467 | 0.85% | Shares |
| DEUTSCHE BANK AG\ | $5,506,652 | 1,040,955 | 0.85% | Shares |
| NORTHERN TRUST CORP | $5,283,456 | 998,763 | 0.82% | Shares |
| KOTLER KEVIN | $5,134,846 | 1,705,929 | 0.79% | Shares |
| Aldebaran Capital, LLC | $4,955,307 | 936,731 | 0.77% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $4,798,945 | 907,173 | 0.74% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $4,324,739 | 817,531 | 0.67% | Shares |
| Three Bridge Wealth Advisors, LLC | $3,781,414 | 714,823 | 0.58% | Shares |
| GOLDMAN SACHS GROUP INC | $3,222,447 | 609,158 | 0.50% | Shares |
| MILLENNIUM MANAGEMENT LLC | $2,771,405 | 523,895 | 0.43% | Shares |
| CITADEL ADVISORS LLC | $2,756,090 | 521,000 | 0.43% | Call option |
| DIMENSIONAL FUND ADVISORS LP | $2,714,467 | 513,840 | 0.42% | Shares |
| JPMORGAN CHASE & CO | $2,354,200 | 468,964 | 0.36% | Shares |
| Aisling Capital Management LP | $2,298,267 | 434,455 | 0.36% | Shares |
| ORBIMED ADVISORS LLC | $2,229,735 | 421,500 | 0.34% | Shares |
| D. E. Shaw & Co., Inc. | $2,192,700 | 414,499 | 0.34% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2,182,384 | 412,549 | 0.34% | Shares |
| Tetragon Partners GP Ltd | $2,116,000 | 400,000 | 0.33% | Shares |
| Russell Investments Group, Ltd. | $1,931,139 | 365,055 | 0.30% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1,830,647 | 346,058 | 0.28% | Shares |
| FMR LLC | $1,660,267 | 313,850 | 0.26% | Shares |
| Bank of New York Mellon Corp | $1,494,949 | 282,599 | 0.23% | Shares |
| Nuveen, LLC | $1,472,758 | 278,404 | 0.23% | Shares |
| RAYMOND JAMES FINANCIAL INC | $1,457,982 | 275,611 | 0.23% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $1,415,064 | 267,498 | 0.22% | Shares |
| SUPERSTRING CAPITAL MANAGEMENT LP | $1,363,101 | 257,675 | 0.21% | Shares |
| UBS Group AG | $1,359,536 | 257,001 | 0.21% | Shares |
| Invesco Ltd. | $1,285,618 | 243,028 | 0.20% | Shares |
| HighTower Advisors, LLC | $1,150,702 | 217,524 | 0.18% | Shares |
| Creative Planning | $1,093,163 | 206,647 | 0.17% | Shares |
| Logos Global Management LP | $1,058,000 | 200,000 | 0.16% | Shares |
| Verdad Advisers, LP | $927,189 | 175,272 | 0.14% | Shares |
| Informed Momentum Co LLC | $906,320 | 171,327 | 0.14% | Shares |
| Assenagon Asset Management S.A. | $817,591 | 154,554 | 0.13% | Shares |
| Atom Investors LP | $787,443 | 148,855 | 0.12% | Shares |
| TWO SIGMA ADVISERS, LP | $768,754 | 255,400 | 0.12% | Shares |
| RHUMBLINE ADVISERS | $757,603 | 143,216 | 0.12% | Shares |
| ALPS ADVISORS INC | $749,852 | 141,749 | 0.12% | Shares |
| SEI INVESTMENTS CO | $734,136 | 138,778 | 0.11% | Shares |
| MORGAN STANLEY | $709,477 | 134,117 | 0.11% | Shares |
| TWO SIGMA INVESTMENTS, LP | $703,930 | 133,068 | 0.11% | Shares |
| Vanguard Global Advisers, LLC | $682,706 | 129,056 | 0.11% | Shares |
| Hudson Bay Capital Management LP | $634,800 | 120,000 | 0.10% | Shares |
| CenterBook Partners LP | $625,426 | 118,228 | 0.10% | Shares |
| CITIGROUP INC | $623,088 | 117,786 | 0.10% | Shares |
| BANK OF AMERICA CORP /DE/ | $584,080 | 110,412 | 0.09% | Shares |
| WELLS FARGO & COMPANY/MN | $574,748 | 108,648 | 0.09% | Shares |
| CITADEL ADVISORS LLC | $550,160 | 104,000 | 0.09% | Put option |
| Verition Fund Management LLC | $518,420 | 98,000 | 0.08% | Shares |
| STRS OHIO | $430,606 | 81,400 | 0.07% | Shares |
| Voleon Capital Management LP | $408,219 | 77,168 | 0.06% | Shares |
| Susquehanna Portfolio Strategies, LLC | $403,468 | 76,270 | 0.06% | Shares |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $396,851 | 75,019 | 0.06% | Shares |
| BARCLAYS PLC | $386,223 | 73,010 | 0.06% | Shares |
| MetLife Investment Management, LLC | $368,708 | 69,699 | 0.06% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $318,771 | 60,259 | 0.05% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $288,718 | 54,578 | 0.04% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $280,899 | 53,100 | 0.04% | Put option |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $271,906 | 51,400 | 0.04% | Call option |
| MANGROVE PARTNERS IM, LLC | $266,039 | 50,291 | 0.04% | Shares |
| DIVERSIFIED TRUST CO | $240,816 | 45,523 | 0.04% | Shares |
| ALLIANCEBERNSTEIN L.P. | $213,750 | 57,000 | 0.03% | Shares |
| Police & Firemen's Retirement System of New Jersey | $205,390 | 38,826 | 0.03% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $187,922 | 35,524 | 0.03% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $171,428 | 32,406 | 0.03% | Shares |
| PROFUND ADVISORS LLC | $161,271 | 30,486 | 0.02% | Shares |
| State of Wyoming | $145,152 | 27,439 | 0.02% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $144,417 | 27,300 | 0.02% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $130,494 | 24,668 | 0.02% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $122,220 | 23,104 | 0.02% | Shares |
| China Universal Asset Management Co., Ltd. | $117,586 | 22,228 | 0.02% | Shares |
| Rafferty Asset Management, LLC | $116,364 | 21,997 | 0.02% | Shares |
| PRUDENTIAL FINANCIAL INC | $107,228 | 20,270 | 0.02% | Shares |
| ProShare Advisors LLC | $106,302 | 20,095 | 0.02% | Shares |
| Verition Fund Management LLC | $105,800 | 20,000 | 0.02% | Call option |
| Walleye Capital LLC | $103,557 | 19,576 | 0.02% | Shares |
| NEUBERGER BERMAN GROUP LLC | $102,451 | 19,367 | 0.02% | Shares |
| Vontobel Holding Ltd. | $95,220 | 18,000 | 0.01% | Shares |
| CRA Financial Services, LLC | $94,067 | 17,782 | 0.01% | Shares |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | $85,021 | 16,072 | 0.01% | Shares |
| Vanguard Personalized Indexing Management, LLC | $83,005 | 15,691 | 0.01% | Shares |
| Dynamic Technology Lab Private Ltd | $72,000 | 13,521 | 0.01% | Shares |
| VICTORY CAPITAL MANAGEMENT INC | $67,278 | 12,718 | 0.01% | Shares |
| TWO SIGMA SECURITIES, LLC | $67,030 | 12,671 | 0.01% | Shares |
| Legal & General Group Plc | $60,930 | 11,518 | 0.01% | Shares |
| XPONANCE LLC | $59,634 | 11,273 | 0.01% | Shares |
| Jefferies Financial Group Inc. | $58,190 | 11,000 | 0.01% | Shares |
| Quadrature Capital Ltd | $57,635 | 10,895 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $56,899 | 10,756 | 0.01% | Shares |
| MERCER GLOBAL ADVISORS INC /ADV | $56,540 | 10,688 | 0.01% | Shares |
| M&T Bank Corp | $55,630 | 10,516 | 0.01% | Shares |
| JANE STREET GROUP, LLC | $54,487 | 10,300 | 0.01% | Call option |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $50,260 | 9,501 | 0.01% | Shares |
| Tower Research Capital LLC (TRC) | $39,728 | 7,510 | 0.01% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $33,041 | 6,246 | 0.01% | Shares |
| Rockefeller Capital Management L.P. | $32,333 | 6,112 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $30,031 | 5,677 | 0.00% | Shares |
| SIMPLEX TRADING, LLC | $29,089 | 5,499 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $23,000 | 4,394 | 0.00% | Shares |
| Quantbot Technologies LP | $20,033 | 3,787 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $13,505 | 2,553 | 0.00% | Shares |
| PNC Financial Services Group, Inc. | $10,924 | 2,065 | 0.00% | Shares |
| ACADIAN ASSET MANAGEMENT LLC | $8,677 | 1,641,472 | 0.00% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $6,798 | 1,285 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $6,216 | 1,175 | 0.00% | Shares |
| GAMMA Investing LLC | $5,396 | 1,020 | 0.00% | Shares |
| CWM, LLC | $5,093 | 1,358 | 0.00% | Shares |
| Arax Advisory Partners | $4,158 | 786 | 0.00% | Shares |
| OSAIC HOLDINGS, INC. | $3,887 | 735 | 0.00% | Shares |
| Sterling Capital Management LLC | $3,629 | 686 | 0.00% | Shares |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | $2,645 | 500 | 0.00% | Shares |
| HUNTINGTON NATIONAL BANK | $2,423 | 458 | 0.00% | Shares |
| Bollard Group LLC | $2,283 | 431,631 | 0.00% | Shares |
| MassMutual Private Wealth & Trust, FSB | $2,068 | 391 | 0.00% | Shares |
| Parallel Advisors, LLC | $1,889 | 357 | 0.00% | Shares |
| Smartleaf Asset Management LLC | $1,888 | 376 | 0.00% | Shares |
| Optiver Holding B.V. | $1,777 | 336 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $1,682 | 318 | 0.00% | Shares |
| Cornerstone Financial Management LLC | $1,428 | 270 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $1,173 | 221,599 | 0.00% | Shares |
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ | $825 | 156 | 0.00% | Shares |
| Truvestments Capital LLC | $794 | 150 | 0.00% | Shares |
| SJS Investment Consulting Inc. | $540 | 102 | 0.00% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $540 | 102 | 0.00% | Shares |
| Allworth Financial LP | $461 | 87 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $354 | 67 | 0.00% | Shares |
| Fortitude Family Office, LLC | $296 | 56 | 0.00% | Shares |
| Cambridge Investment Research Advisors, Inc. | $222 | 41,873 | 0.00% | Shares |
| SG Americas Securities, LLC | $184 | 34,814 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $101 | 19 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $48 | 9 | 0.00% | Shares |
| Clearstead Advisors, LLC | $32 | 6 | 0.00% | Shares |
| Essential Partners LLC | $26 | 5 | 0.00% | Shares |
| Motiv8 Investments LLC | $3 | 1,000 | 0.00% | Shares |
| Capital Advisors, Ltd. LLC | $2 | 454 | 0.00% | Shares |