KOD — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | $776,051,487 | 19,919,186 | 34.06% | Shares |
| BlackRock, Inc. | $161,113,431 | 4,135,355 | 7.07% | Shares |
| STATE STREET CORP | $94,260,486 | 2,419,417 | 4.14% | Shares |
| GOLDMAN SACHS GROUP INC | $90,231,905 | 2,316,014 | 3.96% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $70,308,463 | 1,804,632 | 3.09% | Shares |
| BRAIDWELL LP | $69,633,909 | 1,787,318 | 3.06% | Shares |
| VANGUARD GROUP INC | $64,682,524 | 2,313,395 | 2.84% | Shares |
| RTW INVESTMENTS, LP | $57,969,909 | 1,487,934 | 2.54% | Shares |
| Boxer Capital Management, LLC | $57,567,296 | 1,477,600 | 2.53% | Shares |
| TCG Crossover Management, LLC | $56,318,161 | 1,445,538 | 2.47% | Shares |
| JANUS HENDERSON GROUP PLC | $50,539,675 | 1,325,457 | 2.22% | Shares |
| ICONIQ Capital, LLC | $49,345,294 | 1,266,563 | 2.17% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $41,420,974 | 1,062,955 | 1.82% | Shares |
| Ikarian Capital, LLC | $41,287,080 | 1,059,730 | 1.81% | Shares |
| Artisan Partners Limited Partnership | $37,714,722 | 968,037 | 1.66% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $30,919,164 | 793,613 | 1.36% | Shares |
| Board of Trustees of The Leland Stanford Junior University | $26,951,242 | 691,767 | 1.18% | Shares |
| SILVERARC CAPITAL MANAGEMENT, LLC | $21,282,134 | 546,256 | 0.93% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $20,758,628 | 532,819 | 0.91% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $19,480,000 | 500,000 | 0.85% | Shares |
| Squadron Capital Management LLC | $19,480,000 | 500,000 | 0.85% | Shares |
| TWO SIGMA INVESTMENTS, LP | $18,428,119 | 473,001 | 0.81% | Shares |
| MORGAN STANLEY | $16,948,748 | 435,029 | 0.74% | Shares |
| BANK OF AMERICA CORP /DE/ | $14,949,303 | 383,709 | 0.66% | Shares |
| BOONE CAPITAL MANAGEMENT LLC | $14,727,270 | 378,010 | 0.65% | Shares |
| NORTHERN TRUST CORP | $14,291,579 | 366,827 | 0.63% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $13,949,862 | 358,056 | 0.61% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $12,174,462 | 312,595 | 0.53% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $11,375,112 | 291,969 | 0.50% | Shares |
| FMR LLC | $10,791,298 | 276,984 | 0.47% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $10,344,815 | 265,524 | 0.45% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9,346,504 | 239,900 | 0.41% | Call option |
| DIADEMA PARTNERS LP | $8,497,838 | 218,117 | 0.37% | Shares |
| Ikarian Capital, LLC | $8,481,592 | 217,700 | 0.37% | Call option |
| D. E. Shaw & Co., Inc. | $8,232,248 | 211,300 | 0.36% | Shares |
| DIADEMA PARTNERS LP | $7,663,432 | 196,700 | 0.34% | Call option |
| TD Asset Management Inc | $7,563,383 | 194,132 | 0.33% | Shares |
| PFM Health Sciences, LP | $7,531,552 | 193,315 | 0.33% | Shares |
| UBS Group AG | $7,406,880 | 190,115 | 0.33% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $7,371,232 | 189,200 | 0.32% | Shares |
| ALGERT GLOBAL LLC | $7,265,105 | 186,476 | 0.32% | Shares |
| Nuveen, LLC | $6,807,481 | 174,730 | 0.30% | Shares |
| CITADEL ADVISORS LLC | $6,137,135 | 157,524 | 0.27% | Shares |
| Squarepoint Ops LLC | $5,886,778 | 151,098 | 0.26% | Shares |
| Ghisallo Capital Management LLC | $5,844,000 | 150,000 | 0.26% | Shares |
| DIADEMA PARTNERS LP | $5,723,224 | 146,900 | 0.25% | Put option |
| Bruce & Co., Inc. | $5,649,200 | 145,000 | 0.25% | Shares |
| FEDERATED HERMES, INC. | $5,612,772 | 144,065 | 0.25% | Shares |
| PRUDENTIAL FINANCIAL INC | $4,694,485 | 120,495 | 0.21% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $4,444,907 | 114,089 | 0.20% | Shares |
| Bank of New York Mellon Corp | $4,360,988 | 111,935 | 0.19% | Shares |
| CITADEL ADVISORS LLC | $4,266,120 | 109,500 | 0.19% | Call option |
| WELLS FARGO & COMPANY/MN | $3,928,921 | 100,845 | 0.17% | Shares |
| CITADEL ADVISORS LLC | $3,884,312 | 99,700 | 0.17% | Put option |
| Harvest Investment Services, LLC | $3,812,080 | 97,846 | 0.17% | Shares |
| Point72 Asset Management, L.P. | $3,802,379 | 97,597 | 0.17% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $3,775,146 | 96,898 | 0.17% | Shares |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $3,662,824 | 94,015 | 0.16% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3,631,072 | 93,200 | 0.16% | Put option |
| VICTORY CAPITAL MANAGEMENT INC | $3,491,206 | 89,610 | 0.15% | Shares |
| RIA Advisory Group LLC | $3,398,442 | 87,229 | 0.15% | Shares |
| JPMORGAN CHASE & CO | $3,383,429 | 87,824 | 0.15% | Shares |
| Caption Management, LLC | $3,186,928 | 81,800 | 0.14% | Call option |
| SPHERA FUNDS MANAGEMENT LTD. | $3,186,772 | 81,796 | 0.14% | Shares |
| Atom Investors LP | $2,993,803 | 76,843 | 0.13% | Shares |
| STEMPOINT CAPITAL LP | $2,955,973 | 75,872 | 0.13% | Shares |
| Invesco Ltd. | $2,901,156 | 74,465 | 0.13% | Shares |
| TWO SIGMA ADVISERS, LP | $2,882,676 | 103,100 | 0.13% | Shares |
| Qube Research & Technologies Ltd | $2,882,183 | 73,978 | 0.13% | Shares |
| FRANKLIN RESOURCES INC | $2,769,900 | 71,096 | 0.12% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $2,639,812 | 67,757 | 0.12% | Shares |
| ExodusPoint Capital Management, LP | $2,636,501 | 67,672 | 0.12% | Shares |
| Pictet Asset Management Holding SA | $2,497,778 | 66,015 | 0.11% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $2,446,688 | 62,800 | 0.11% | Call option |
| CITIGROUP INC | $2,430,325 | 62,380 | 0.11% | Shares |
| Swiss National Bank | $2,415,520 | 62,000 | 0.11% | Shares |
| Persistent Asset Partners Ltd | $2,183,786 | 56,052 | 0.10% | Shares |
| Emerald Investment Advisers, LLC | $2,167,384 | 55,631 | 0.10% | Shares |
| DEUTSCHE BANK AG\ | $2,156,320 | 55,347 | 0.09% | Shares |
| Jain Global LLC | $2,151,098 | 55,213 | 0.09% | Shares |
| Resolute Capital Asset Partners LLC | $2,001,960 | 51,385 | 0.09% | Shares |
| RHUMBLINE ADVISERS | $1,955,700 | 50,198 | 0.09% | Shares |
| Informed Momentum Co LLC | $1,894,157 | 48,618 | 0.08% | Shares |
| Balyasny Asset Management L.P. | $1,809,536 | 46,446 | 0.08% | Shares |
| ALLIANCEBERNSTEIN L.P. | $1,800,026 | 47,220 | 0.08% | Shares |
| STATE OF WISCONSIN INVESTMENT BOARD | $1,717,123 | 44,074 | 0.08% | Shares |
| JANE STREET GROUP, LLC | $1,706,448 | 43,800 | 0.07% | Call option |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1,667,788 | 43,751 | 0.07% | Shares |
| Rafferty Asset Management, LLC | $1,619,294 | 41,563 | 0.07% | Shares |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $1,585,672 | 40,700 | 0.07% | Shares |
| HighVista Strategies LLC | $1,581,387 | 40,590 | 0.07% | Shares |
| POLEN CAPITAL MANAGEMENT LLC | $1,381,872 | 35,469 | 0.06% | Shares |
| Russell Investments Group, Ltd. | $1,358,566 | 34,870 | 0.06% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1,335,977 | 34,291 | 0.06% | Shares |
| PANAGORA ASSET MANAGEMENT INC | $1,332,042 | 34,190 | 0.06% | Shares |
| Caption Management, LLC | $1,297,368 | 33,300 | 0.06% | Put option |
| MILLENNIUM MANAGEMENT LLC | $1,213,760 | 31,154 | 0.05% | Shares |
| Vanguard Global Advisers, LLC | $1,192,955 | 30,620 | 0.05% | Shares |
| Trexquant Investment LP | $1,171,332 | 30,065 | 0.05% | Shares |
| Engineers Gate Manager LP | $1,150,762 | 29,537 | 0.05% | Shares |
| Legal & General Group Plc | $1,141,880 | 29,309 | 0.05% | Shares |
| XTX Topco Ltd | $1,140,009 | 29,261 | 0.05% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $986,390 | 25,318 | 0.04% | Shares |
| Aries Wealth Management | $974,000 | 25,000 | 0.04% | Shares |
| VANGUARD ASSET MANAGEMENT, Ltd | $947,079 | 24,309 | 0.04% | Shares |
| State of Wyoming | $905,586 | 23,244 | 0.04% | Shares |
| MetLife Investment Management, LLC | $895,418 | 22,983 | 0.04% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $888,476 | 22,956 | 0.04% | Shares |
| BARCLAYS PLC | $819,717 | 21,040 | 0.04% | Shares |
| PROFUND ADVISORS LLC | $819,524 | 21,035 | 0.04% | Shares |
| Y-Intercept (Hong Kong) Ltd | $723,137 | 18,561 | 0.03% | Shares |
| OPTIMIZE FINANCIAL INC. | $692,202 | 17,767 | 0.03% | Shares |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $682,774 | 17,525 | 0.03% | Shares |
| Artia Global Partners LP | $663,060 | 17,019 | 0.03% | Shares |
| SEI INVESTMENTS CO | $620,547 | 15,928 | 0.03% | Shares |
| Vanguard Personalized Indexing Management, LLC | $606,296 | 15,562 | 0.03% | Shares |
| Palumbo Wealth Management LLC | $605,478 | 15,541 | 0.03% | Shares |
| SIMPLEX TRADING, LLC | $569,205 | 14,610 | 0.02% | Shares |
| Brevan Howard Capital Management LP | $546,336 | 14,023 | 0.02% | Shares |
| Edgestream Partners, L.P. | $527,207 | 13,532 | 0.02% | Shares |
| Continuum Advisory, LLC | $520,194 | 13,352 | 0.02% | Shares |
| FRED ALGER MANAGEMENT, LLC | $501,220 | 12,865 | 0.02% | Shares |
| LPL Financial LLC | $491,753 | 12,622 | 0.02% | Shares |
| Cerity Partners LLC | $488,871 | 12,548 | 0.02% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $478,702 | 12,287 | 0.02% | Shares |
| Campbell & CO Investment Adviser LLC | $476,442 | 12,229 | 0.02% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $460,624 | 11,823 | 0.02% | Shares |
| Quantinno Capital Management LP | $453,066 | 11,629 | 0.02% | Shares |
| Creative Planning | $445,430 | 11,433 | 0.02% | Shares |
| Police & Firemen's Retirement System of New Jersey | $422,755 | 10,851 | 0.02% | Shares |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $404,989 | 10,395 | 0.02% | Shares |
| State of New Jersey Common Pension Fund D | $389,561 | 9,999 | 0.02% | Shares |
| China Universal Asset Management Co., Ltd. | $388,003 | 9,959 | 0.02% | Shares |
| Virtus Investment Advisers, LLC | $374,250 | 9,606 | 0.02% | Shares |
| STIFEL FINANCIAL CORP | $369,193 | 9,476 | 0.02% | Shares |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $360,926 | 9,264 | 0.02% | Shares |
| Skopos Labs, Inc. | $346,473 | 9,089 | 0.02% | Shares |
| Persistent Asset Partners Ltd | $344,930 | 372 | 0.02% | Put option |
| ARIZONA STATE RETIREMENT SYSTEM | $332,446 | 8,533 | 0.01% | Shares |
| ALLSTATE CORP | $327,615 | 8,409 | 0.01% | Shares |
| Vanguard Investments Australia, Ltd. | $319,472 | 8,200 | 0.01% | Shares |
| NORGES BANK | $298,083 | 7,651 | 0.01% | Shares |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $287,914 | 7,390 | 0.01% | Shares |
| J. Goldman & Co LP | $284,759 | 7,309 | 0.01% | Shares |
| ProShare Advisors LLC | $280,784 | 7,207 | 0.01% | Shares |
| AMERICAN CENTURY COMPANIES INC | $255,032 | 6,546 | 0.01% | Shares |
| KLP KAPITALFORVALTNING AS | $249,344 | 6,400 | 0.01% | Shares |
| MANGROVE PARTNERS IM, LLC | $239,565 | 6,149 | 0.01% | Shares |
| PSP Research LLC | $233,760 | 6,000 | 0.01% | Shares |
| HSBC HOLDINGS PLC | $232,415 | 6,004 | 0.01% | Shares |
| E Fund Management Co., Ltd. | $228,345 | 5,861 | 0.01% | Shares |
| Persistent Asset Partners Ltd | $215,919 | 502 | 0.01% | Call option |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $206,605 | 5,303 | 0.01% | Shares |
| VARCOV Co. | $204,696 | 5,254 | 0.01% | Shares |
| GROUP ONE TRADING LLC | $153,580 | 3,942 | 0.01% | Shares |
| Mitsubishi UFJ Trust & Banking Corp | $145,827 | 3,743 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $139,204 | 3,573 | 0.01% | Shares |
| CWM, LLC | $131,476 | 3,449 | 0.01% | Shares |
| ROYAL BANK OF CANADA | $131,000 | 3,362 | 0.01% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $126,567 | 3,248,611 | 0.01% | Shares |
| Tower Research Capital LLC (TRC) | $115,360 | 2,961 | 0.01% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $113,023 | 2,901 | 0.00% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $109,049 | 2,799 | 0.00% | Shares |
| Bayforest Capital Ltd | $105,932 | 2,719 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $96,582 | 2,479 | 0.00% | Shares |
| T. Rowe Price Investment Management, Inc. | $57,546 | 1,477,033 | 0.00% | Shares |
| STRS OHIO | $50,648 | 1,300 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $50,414 | 1,294 | 0.00% | Shares |
| PNC Financial Services Group, Inc. | $47,414 | 1,217 | 0.00% | Shares |
| Point72 (DIFC) Ltd | $41,183 | 2,516 | 0.00% | Shares |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $39,622 | 1,017 | 0.00% | Shares |
| Activest Wealth Management | $38,999 | 1,001 | 0.00% | Shares |
| GAMMA Investing LLC | $34,752 | 892 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $27,876 | 730 | 0.00% | Shares |
| FIFTH THIRD BANCORP | $27,496 | 706 | 0.00% | Shares |
| V-Square Quantitative Management LLC | $26,960 | 692 | 0.00% | Shares |
| Larson Financial Group LLC | $25,675 | 659 | 0.00% | Shares |
| OSAIC HOLDINGS, INC. | $24,895 | 639 | 0.00% | Shares |
| Spire Wealth Management | $24,662 | 633 | 0.00% | Shares |
| Physician Wealth Advisors, Inc. | $23,766 | 610 | 0.00% | Shares |
| Ameritas Advisory Services, LLC | $20,727 | 532 | 0.00% | Shares |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $17,610 | 452 | 0.00% | Shares |
| Allworth Financial LP | $15,000 | 385 | 0.00% | Shares |
| TOKIO MARINE ASSET MANAGEMENT CO LTD | $13,285 | 341 | 0.00% | Shares |
| Accent Capital Management, LLC | $8,844 | 227 | 0.00% | Shares |
| Arax Advisory Partners | $7,247 | 186 | 0.00% | Shares |
| Silver Grove Financial Group, Inc. | $5,922 | 152 | 0.00% | Shares |
| AlphaQuest LLC | $5,872 | 210 | 0.00% | Shares |
| Sterling Capital Management LLC | $5,376 | 138 | 0.00% | Shares |
| Fortitude Family Office, LLC | $2,961 | 76 | 0.00% | Shares |
| Bare Financial Services, Inc | $1,714 | 44 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $1,636 | 42 | 0.00% | Shares |
| FINANCIAL CONSULATE, INC | $1,169 | 30 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $1,072 | 27,525 | 0.00% | Shares |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $990 | 25,419 | 0.00% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $818 | 21 | 0.00% | Shares |
| SG Americas Securities, LLC | $781 | 20,057 | 0.00% | Shares |
| Parkside Financial Bank & Trust | $585 | 15 | 0.00% | Shares |
| True Wealth Design, LLC | $507 | 13 | 0.00% | Shares |
| Quarry LP | $468 | 12 | 0.00% | Shares |
| Keating Financial Advisory Services, Inc. | $390 | 10 | 0.00% | Shares |
| Axiom Investment Management LLC | $390 | 10 | 0.00% | Shares |
| Global Retirement Partners, LLC | $273 | 7 | 0.00% | Shares |
| Smartleaf Asset Management LLC | $253 | 6 | 0.00% | Shares |
| IFP Advisors, Inc | $234 | 6 | 0.00% | Shares |
| Essential Partners LLC | $195 | 5 | 0.00% | Shares |
| CANADA LIFE ASSURANCE Co | $192 | 4,951 | 0.00% | Shares |
| Stone House Investment Management, LLC | $156 | 4 | 0.00% | Shares |
| Hughes Financial Services, LLC | $78 | 2 | 0.00% | Shares |
| ACADIAN ASSET MANAGEMENT LLC | $54 | 1,415 | 0.00% | Shares |
| KBC Group NV | $40 | 1,014 | 0.00% | Shares |
| Pacer Advisors, Inc. | $27 | 694 | 0.00% | Shares |
| Avion Wealth | $13 | 352 | 0.00% | Shares |
| Covestor Ltd | $1 | 17 | 0.00% | Shares |