MBX — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | $367,191,118 | 6,652,013 | 11.84% | Shares |
| FMR LLC | $293,823,234 | 5,322,885 | 9.47% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $274,759,269 | 4,977,523 | 8.86% | Shares |
| NEA Management Company, LLC | $199,519,627 | 3,614,486 | 6.43% | Shares |
| ORBIMED ADVISORS LLC | $189,266,227 | 3,428,736 | 6.10% | Shares |
| BlackRock, Inc. | $183,466,695 | 3,323,672 | 5.91% | Shares |
| Paradigm Biocapital Advisors LP | $138,442,428 | 2,508,015 | 4.46% | Shares |
| NVP ASSOCIATES, LLC | $117,925,692 | 2,136,335 | 3.80% | Shares |
| Deep Track Capital, LP | $95,637,809 | 1,732,569 | 3.08% | Shares |
| Polar Capital Holdings Plc | $88,789,973 | 1,608,514 | 2.86% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $81,551,818 | 1,477,388 | 2.63% | Shares |
| Aaron Wealth Advisors LLC | $64,462,505 | 1,167,799 | 2.08% | Shares |
| Driehaus Capital Management LLC | $58,323,161 | 1,056,579 | 1.88% | Shares |
| VANGUARD GROUP INC | $57,333,759 | 1,817,811 | 1.85% | Shares |
| Kynam Capital Management, LP | $51,600,905 | 934,799 | 1.66% | Shares |
| Woodline Partners LP | $49,685,078 | 900,092 | 1.60% | Shares |
| EVENTIDE ASSET MANAGEMENT, LLC | $48,216,758 | 873,492 | 1.55% | Shares |
| STATE STREET CORP | $47,718,523 | 864,466 | 1.54% | Shares |
| Parkman Healthcare Partners LLC | $44,169,550 | 800,173 | 1.42% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $42,683,039 | 773,072 | 1.38% | Shares |
| BRAIDWELL LP | $39,240,576 | 710,880 | 1.26% | Shares |
| TCG Crossover Management, LLC | $35,880,000 | 650,000 | 1.16% | Shares |
| Cormorant Asset Management, LP | $30,360,000 | 550,000 | 0.98% | Shares |
| Soleus Capital Management, L.P. | $28,443,401 | 515,279 | 0.92% | Shares |
| GOLDMAN SACHS GROUP INC | $25,337,076 | 459,005 | 0.82% | Shares |
| MARSHALL WACE, LLP | $22,184,052 | 401,885 | 0.72% | Shares |
| EcoR1 Capital, LLC | $21,445,200 | 388,500 | 0.69% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $19,138,778 | 346,717 | 0.62% | Shares |
| BANK OF AMERICA CORP /DE/ | $16,500,771 | 298,927 | 0.53% | Shares |
| Rock Springs Capital Management LP | $16,461,634 | 298,218 | 0.53% | Shares |
| Candriam S.C.A. | $15,986,698 | 289,893 | 0.52% | Shares |
| UBS Group AG | $15,055,635 | 272,747 | 0.49% | Shares |
| Opaleye Management Inc. | $14,352,000 | 260,000 | 0.46% | Shares |
| FRANKLIN RESOURCES INC | $13,947,108 | 252,665 | 0.45% | Shares |
| Schonfeld Strategic Advisors LLC | $13,726,583 | 248,670 | 0.44% | Shares |
| MORGAN STANLEY | $13,720,403 | 248,558 | 0.44% | Shares |
| NORTHERN TRUST CORP | $13,616,626 | 246,678 | 0.44% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $12,900,240 | 233,700 | 0.42% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $12,866,844 | 233,095 | 0.41% | Shares |
| MILLENNIUM MANAGEMENT LLC | $12,483,535 | 226,151 | 0.40% | Shares |
| Tetragon Partners GP Ltd | $11,235,574 | 203,543 | 0.36% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $11,118,881 | 201,429 | 0.36% | Shares |
| Caption Management, LLC | $11,040,000 | 200,000 | 0.36% | Call option |
| Caption Management, LLC | $11,040,000 | 200,000 | 0.36% | Put option |
| Caligan Partners LP | $11,040,000 | 200,000 | 0.36% | Shares |
| D. E. Shaw & Co., Inc. | $10,088,738 | 182,767 | 0.33% | Shares |
| JPMORGAN CHASE & CO | $7,518,053 | 139,611 | 0.24% | Shares |
| KVP Capital Advisors, LP | $6,708,125 | 121,524 | 0.22% | Shares |
| TWO SIGMA INVESTMENTS, LP | $6,263,820 | 113,475 | 0.20% | Shares |
| Burkehill Global Management, LP | $5,520,000 | 100,000 | 0.18% | Shares |
| Nuveen, LLC | $5,450,062 | 98,733 | 0.18% | Shares |
| TD Asset Management Inc | $5,277,010 | 95,598 | 0.17% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5,210,880 | 94,400 | 0.17% | Call option |
| Elmind Capital, LP | $5,023,200 | 91,000 | 0.16% | Shares |
| Bank of New York Mellon Corp | $4,908,760 | 88,927 | 0.16% | Shares |
| PRUDENTIAL FINANCIAL INC | $4,860,084 | 88,045 | 0.16% | Shares |
| BARCLAYS PLC | $4,849,540 | 87,854 | 0.16% | Shares |
| Affinity Asset Advisors, LLC | $4,140,000 | 75,000 | 0.13% | Shares |
| PFM Health Sciences, LP | $3,917,599 | 70,971 | 0.13% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $3,883,486 | 70,353 | 0.13% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $3,649,382 | 66,112 | 0.12% | Shares |
| MOORE CAPITAL MANAGEMENT, LP | $3,582,094 | 64,893 | 0.12% | Shares |
| Rhenman & Partners Asset Management AB | $3,422,400 | 62,000 | 0.11% | Shares |
| Invesco Ltd. | $2,797,425 | 50,678 | 0.09% | Shares |
| ALPS ADVISORS INC | $2,650,262 | 48,012 | 0.09% | Shares |
| PLATINUM INVESTMENT MANAGEMENT LTD | $2,406,554 | 43,597 | 0.08% | Shares |
| Swiss National Bank | $2,368,080 | 42,900 | 0.08% | Shares |
| Ensign Peak Advisors, Inc | $2,327,011 | 42,156 | 0.08% | Shares |
| ALGERT GLOBAL LLC | $2,322,264 | 42,070 | 0.07% | Shares |
| Creative Planning | $2,181,724 | 39,524 | 0.07% | Shares |
| JANE STREET GROUP, LLC | $2,075,520 | 37,600 | 0.07% | Call option |
| RHUMBLINE ADVISERS | $2,053,213 | 37,196 | 0.07% | Shares |
| DEUTSCHE BANK AG\ | $1,749,454 | 31,693 | 0.06% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1,711,200 | 31,000 | 0.06% | Put option |
| WELLS FARGO & COMPANY/MN | $1,562,878 | 28,313 | 0.05% | Shares |
| EXCHANGE TRADED CONCEPTS, LLC | $1,513,639 | 27,421 | 0.05% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1,472,957 | 26,684 | 0.05% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $1,442,486 | 26,132 | 0.05% | Shares |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $1,424,160 | 25,800 | 0.05% | Shares |
| CITIGROUP INC | $1,386,734 | 25,122 | 0.04% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1,290,355 | 23,376 | 0.04% | Shares |
| AMERICAN CENTURY COMPANIES INC | $1,251,936 | 22,680 | 0.04% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $1,247,023 | 22,591 | 0.04% | Shares |
| CITADEL ADVISORS LLC | $1,236,480 | 22,400 | 0.04% | Call option |
| Legal & General Group Plc | $1,191,382 | 21,583 | 0.04% | Shares |
| Cerity Partners LLC | $1,159,034 | 20,997 | 0.04% | Shares |
| Vanguard Global Advisers, LLC | $1,047,089 | 18,969 | 0.03% | Shares |
| MetLife Investment Management, LLC | $1,007,400 | 18,250 | 0.03% | Shares |
| Russell Investments Group, Ltd. | $1,002,541 | 18,162 | 0.03% | Shares |
| Koa Wealth Management, LLC | $944,638 | 17,113 | 0.03% | Shares |
| ALLIANCEBERNSTEIN L.P. | $925,350 | 31,000 | 0.03% | Shares |
| STATE OF WISCONSIN INVESTMENT BOARD | $881,599 | 15,971 | 0.03% | Shares |
| VANGUARD ASSET MANAGEMENT, Ltd | $814,310 | 14,752 | 0.03% | Shares |
| OPTIMIZE FINANCIAL INC. | $798,082 | 14,458 | 0.03% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $788,918 | 14,292 | 0.03% | Shares |
| DAFNA Capital Management LLC | $651,857 | 11,809 | 0.02% | Shares |
| HighVista Strategies LLC | $642,197 | 11,634 | 0.02% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $607,200 | 11,000 | 0.02% | Shares |
| FRED ALGER MANAGEMENT, LLC | $545,210 | 9,877 | 0.02% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $544,272 | 9,860 | 0.02% | Shares |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $539,690 | 9,777 | 0.02% | Shares |
| Virtus Investment Advisers, LLC | $508,668 | 9,215 | 0.02% | Shares |
| China Universal Asset Management Co., Ltd. | $506,460 | 9,175 | 0.02% | Shares |
| Police & Firemen's Retirement System of New Jersey | $505,301 | 9,154 | 0.02% | Shares |
| PROFUND ADVISORS LLC | $486,422 | 8,812 | 0.02% | Shares |
| Brevan Howard Capital Management LP | $474,830 | 8,602 | 0.02% | Shares |
| ACT CAPITAL MANAGEMENT, LLC | $441,600 | 8,000 | 0.01% | Shares |
| DNB Asset Management AS | $430,174 | 7,793 | 0.01% | Shares |
| AXQ CAPITAL, LP | $428,186 | 7,757 | 0.01% | Shares |
| State of New Jersey Common Pension Fund D | $381,598 | 6,913 | 0.01% | Shares |
| Quantinno Capital Management LP | $358,634 | 6,497 | 0.01% | Shares |
| Rafferty Asset Management, LLC | $353,832 | 6,410 | 0.01% | Shares |
| XTX Topco Ltd | $352,838 | 6,392 | 0.01% | Shares |
| Vanguard Investments Australia, Ltd. | $336,886 | 6,103 | 0.01% | Shares |
| Seven Fleet Capital Management LP | $331,200 | 6,000 | 0.01% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $328,495 | 5,951 | 0.01% | Shares |
| ARIZONA STATE RETIREMENT SYSTEM | $325,625 | 5,899 | 0.01% | Shares |
| SEI INVESTMENTS CO | $323,914 | 5,868 | 0.01% | Shares |
| ProShare Advisors LLC | $310,335 | 5,622 | 0.01% | Shares |
| JANUS HENDERSON GROUP PLC | $308,176 | 10,300 | 0.01% | Shares |
| Blackstone Inc. | $305,422 | 5,533 | 0.01% | Shares |
| GROUP ONE TRADING LLC | $288,751 | 5,231 | 0.01% | Shares |
| CANADA PENSION PLAN INVESTMENT BOARD | $287,040 | 5,200 | 0.01% | Shares |
| KLP KAPITALFORVALTNING AS | $270,480 | 4,900 | 0.01% | Shares |
| Verdad Advisers, LP | $252,485 | 4,574 | 0.01% | Shares |
| Pictet Asset Management Holding SA | $226,210 | 4,098 | 0.01% | Shares |
| Goelzer Investment Management, Inc. | $220,800 | 4,000 | 0.01% | Shares |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $216,054 | 7,238 | 0.01% | Shares |
| Quantbot Technologies LP | $212,796 | 3,855 | 0.01% | Shares |
| Susquehanna Portfolio Strategies, LLC | $209,760 | 3,800 | 0.01% | Shares |
| CITADEL ADVISORS LLC | $209,760 | 3,800 | 0.01% | Put option |
| Tower Research Capital LLC (TRC) | $201,535 | 3,651 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $155,498 | 2,817 | 0.01% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $117,521 | 2,129 | 0.00% | Shares |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $115,147 | 2,086 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $111,118 | 2,013 | 0.00% | Shares |
| STRS OHIO | $110,400 | 2,000 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $81,000 | 1,464 | 0.00% | Shares |
| SIMPLEX TRADING, LLC | $73,250 | 1,327 | 0.00% | Shares |
| State of Wyoming | $58,236 | 1,055 | 0.00% | Shares |
| CWM, LLC | $52,894 | 1,772 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $52,550 | 952 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $44,978 | 814,807 | 0.00% | Shares |
| Kemnay Advisory Services Inc. | $17,719 | 321 | 0.00% | Shares |
| GAMMA Investing LLC | $16,781 | 304 | 0.00% | Shares |
| OSAIC HOLDINGS, INC. | $15,566 | 282 | 0.00% | Shares |
| Arax Advisory Partners | $15,401 | 279 | 0.00% | Shares |
| Rockefeller Capital Management L.P. | $12,365 | 224 | 0.00% | Shares |
| PNC Financial Services Group, Inc. | $11,426 | 207 | 0.00% | Shares |
| Versant Capital Management, Inc | $10,552 | 180 | 0.00% | Shares |
| FIL Ltd | $9,826 | 178 | 0.00% | Shares |
| Aster Capital Management (DIFC) Ltd | $9,494 | 172 | 0.00% | Shares |
| Physician Wealth Advisors, Inc. | $6,680 | 121 | 0.00% | Shares |
| Sterling Capital Management LLC | $6,017 | 109 | 0.00% | Shares |
| US BANCORP \DE\ | $5,962 | 108 | 0.00% | Shares |
| J.Safra Asset Management Corp | $4,692 | 85 | 0.00% | Shares |
| Parallel Advisors, LLC | $4,361 | 79 | 0.00% | Shares |
| SIGNATUREFD, LLC | $4,306 | 78 | 0.00% | Shares |
| JONES FINANCIAL COMPANIES LLLP | $4,185 | 80 | 0.00% | Shares |
| Keating Financial Advisory Services, Inc. | $2,981 | 54 | 0.00% | Shares |
| Larson Financial Group LLC | $2,705 | 49 | 0.00% | Shares |
| Allworth Financial LP | $2,650 | 48 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $2,649 | 48 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $2,153 | 39 | 0.00% | Shares |
| Cornerstone Financial Management LLC | $1,877 | 34 | 0.00% | Shares |
| Bare Financial Services, Inc | $1,877 | 34 | 0.00% | Shares |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $1,401 | 25,377 | 0.00% | Shares |
| Fortitude Family Office, LLC | $1,049 | 19 | 0.00% | Shares |
| Global Retirement Partners, LLC | $1,049 | 19 | 0.00% | Shares |
| Quarry LP | $994 | 18 | 0.00% | Shares |
| Essential Partners LLC | $828 | 15 | 0.00% | Shares |
| Silver Grove Financial Group, Inc. | $718 | 13 | 0.00% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $607 | 11 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $497 | 9 | 0.00% | Shares |
| SG Americas Securities, LLC | $345 | 6,245 | 0.00% | Shares |
| SJS Investment Consulting Inc. | $111 | 2 | 0.00% | Shares |
| Hughes Financial Services, LLC | $55 | 1 | 0.00% | Shares |
| KBC Group NV | $45 | 810 | 0.00% | Shares |
| Covestor Ltd | $1 | 10 | 0.00% | Shares |