ANNX — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| FMR LLC | $111,450,614 | 19,518,496 | 10.53% | Shares |
| BlackRock, Inc. | $77,311,938 | 13,539,744 | 7.31% | Shares |
| Redmile Group, LLC | $67,776,998 | 11,869,877 | 6.41% | Shares |
| STATE STREET CORP | $56,096,873 | 9,824,321 | 5.30% | Shares |
| BVF INC/IL | $49,666,568 | 8,698,173 | 4.69% | Shares |
| Woodline Partners LP | $39,542,133 | 6,925,067 | 3.74% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $39,233,496 | 6,871,015 | 3.71% | Shares |
| VANGUARD GROUP INC | $38,922,003 | 7,753,387 | 3.68% | Shares |
| MAK CAPITAL ONE LLC | $33,473,048 | 5,862,180 | 3.16% | Shares |
| GOLDMAN SACHS GROUP INC | $33,264,057 | 5,825,579 | 3.14% | Shares |
| Siren, L.L.C. | $25,458,869 | 4,458,646 | 2.41% | Shares |
| Bain Capital Life Sciences Investors, LLC | $25,339,444 | 4,437,731 | 2.39% | Shares |
| Bellevue Group AG | $23,411,091 | 4,100,016 | 2.21% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $23,056,071 | 4,037,193 | 2.18% | Shares |
| MPM BIOIMPACT LLC | $20,238,261 | 3,544,354 | 1.91% | Shares |
| AMERIPRISE FINANCIAL INC | $20,039,948 | 3,509,623 | 1.89% | Shares |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $19,985,000 | 3,500,000 | 1.89% | Shares |
| GREAT POINT PARTNERS LLC | $19,985,000 | 3,500,000 | 1.89% | Shares |
| MORGAN STANLEY | $17,954,827 | 3,144,453 | 1.70% | Shares |
| Palo Alto Investors LP | $16,833,594 | 2,948,090 | 1.59% | Shares |
| Balyasny Asset Management L.P. | $16,164,873 | 2,830,976 | 1.53% | Shares |
| Nuveen, LLC | $15,788,607 | 2,765,080 | 1.49% | Shares |
| Qube Research & Technologies Ltd | $15,702,277 | 2,749,961 | 1.48% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $12,829,228 | 2,246,800 | 1.21% | Shares |
| Opaleye Management Inc. | $9,789,515 | 1,714,451 | 0.93% | Shares |
| Logos Global Management LP | $8,565,000 | 1,500,000 | 0.81% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $8,550,585 | 1,497,756 | 0.81% | Shares |
| Point72 Asset Management, L.P. | $7,895,211 | 1,382,699 | 0.75% | Shares |
| NORTHERN TRUST CORP | $7,720,182 | 1,352,046 | 0.73% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $7,182,032 | 1,257,799 | 0.68% | Shares |
| Tetragon Partners GP Ltd | $7,094,418 | 1,242,455 | 0.67% | Shares |
| Candriam S.C.A. | $6,817,695 | 1,195,142 | 0.64% | Shares |
| MILLENNIUM MANAGEMENT LLC | $6,765,956 | 1,184,931 | 0.64% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $6,312,120 | 1,105,450 | 0.60% | Shares |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $5,923,360 | 1,037,366 | 0.56% | Shares |
| JPMORGAN CHASE & CO | $5,593,995 | 1,004,308 | 0.53% | Shares |
| WELLS FARGO & COMPANY/MN | $5,584,694 | 978,055 | 0.53% | Shares |
| PANAGORA ASSET MANAGEMENT INC | $5,526,857 | 967,926 | 0.52% | Shares |
| KENNEDY CAPITAL MANAGEMENT LLC | $5,129,830 | 898,394 | 0.48% | Shares |
| Ishara Investments LP | $4,682,200 | 820,000 | 0.44% | Shares |
| Ensign Peak Advisors, Inc | $4,570,946 | 800,516 | 0.43% | Shares |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $4,213,609 | 737,935 | 0.40% | Shares |
| Y-Intercept (Hong Kong) Ltd | $4,194,480 | 734,585 | 0.40% | Shares |
| Russell Investments Group, Ltd. | $4,027,213 | 705,291 | 0.38% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $3,950,245 | 691,812 | 0.37% | Shares |
| Parkman Healthcare Partners LLC | $3,660,276 | 641,029 | 0.35% | Shares |
| UBS Group AG | $3,557,866 | 623,094 | 0.34% | Shares |
| DEUTSCHE BANK AG\ | $3,520,153 | 616,489 | 0.33% | Shares |
| BANK OF AMERICA CORP /DE/ | $3,507,002 | 614,186 | 0.33% | Shares |
| CITADEL ADVISORS LLC | $3,406,483 | 596,582 | 0.32% | Shares |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $3,334,143 | 583,913 | 0.32% | Shares |
| SIRIOS CAPITAL MANAGEMENT L P | $3,250,566 | 569,276 | 0.31% | Shares |
| Schonfeld Strategic Advisors LLC | $3,046,666 | 533,567 | 0.29% | Shares |
| TWO SIGMA INVESTMENTS, LP | $2,928,065 | 512,796 | 0.28% | Shares |
| Bank of New York Mellon Corp | $2,863,235 | 501,442 | 0.27% | Shares |
| Board of Trustees of The Leland Stanford Junior University | $2,755,360 | 482,550 | 0.26% | Shares |
| RENAISSANCE TECHNOLOGIES LLC | $2,620,890 | 459,000 | 0.25% | Shares |
| Ikarian Capital, LLC | $2,456,693 | 430,244 | 0.23% | Shares |
| MOORE CAPITAL MANAGEMENT, LP | $2,428,646 | 425,332 | 0.23% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2,352,520 | 412,000 | 0.22% | Call option |
| Trexquant Investment LP | $2,339,199 | 409,667 | 0.22% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $2,322,799 | 406,795 | 0.22% | Shares |
| Susquehanna Portfolio Strategies, LLC | $2,256,763 | 395,230 | 0.21% | Shares |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $2,253,166 | 394,600 | 0.21% | Shares |
| DIADEMA PARTNERS LP | $2,016,772 | 353,200 | 0.19% | Call option |
| Invesco Ltd. | $1,888,463 | 330,729 | 0.18% | Shares |
| Engineers Gate Manager LP | $1,821,815 | 319,057 | 0.17% | Shares |
| DAFNA Capital Management LLC | $1,700,507 | 297,812 | 0.16% | Shares |
| Jump Financial, LLC | $1,700,438 | 297,800 | 0.16% | Shares |
| STATE OF WISCONSIN INVESTMENT BOARD | $1,635,201 | 286,375 | 0.15% | Shares |
| D. E. Shaw & Co., Inc. | $1,514,772 | 265,284 | 0.14% | Shares |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $1,427,643 | 250,025 | 0.13% | Shares |
| Swiss National Bank | $1,396,666 | 244,600 | 0.13% | Shares |
| CITIGROUP INC | $1,347,502 | 235,990 | 0.13% | Shares |
| CITADEL ADVISORS LLC | $1,340,137 | 234,700 | 0.13% | Call option |
| Cinctive Capital Management LP | $1,231,921 | 215,748 | 0.12% | Shares |
| MARSHALL WACE, LLP | $1,202,566 | 210,607 | 0.11% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1,086,042 | 190,200 | 0.10% | Put option |
| RHUMBLINE ADVISERS | $1,082,480 | 189,578 | 0.10% | Shares |
| SEI INVESTMENTS CO | $1,049,635 | 183,817 | 0.10% | Shares |
| Squarepoint Ops LLC | $989,457 | 173,285 | 0.09% | Shares |
| Rafferty Asset Management, LLC | $989,423 | 173,279 | 0.09% | Shares |
| Point72 Europe (London) LLP | $923,726 | 302,861 | 0.09% | Shares |
| OSAIC HOLDINGS, INC. | $842,933 | 147,624 | 0.08% | Shares |
| ALLIANCEBERNSTEIN L.P. | $815,710 | 147,240 | 0.08% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $766,619 | 134,259 | 0.07% | Shares |
| VICTORY CAPITAL MANAGEMENT INC | $727,100 | 127,338 | 0.07% | Shares |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $723,784 | 130,647 | 0.07% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $685,937 | 120,129 | 0.06% | Shares |
| IEQ CAPITAL, LLC | $685,257 | 120,010 | 0.06% | Shares |
| J. Goldman & Co LP | $662,623 | 116,046 | 0.06% | Shares |
| XTX Topco Ltd | $640,359 | 112,147 | 0.06% | Shares |
| Vanguard Global Advisers, LLC | $582,803 | 102,067 | 0.06% | Shares |
| Quarry LP | $571,000 | 100,000 | 0.05% | Shares |
| SCS Capital Management LLC | $565,290 | 99,000 | 0.05% | Shares |
| Legal & General Group Plc | $560,254 | 98,118 | 0.05% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $520,567 | 91,661 | 0.05% | Shares |
| MetLife Investment Management, LLC | $519,639 | 91,005 | 0.05% | Shares |
| JANE STREET GROUP, LLC | $516,755 | 90,500 | 0.05% | Call option |
| J. Safra Sarasin Holding AG | $516,681 | 90,487 | 0.05% | Shares |
| CITADEL ADVISORS LLC | $507,619 | 88,900 | 0.05% | Put option |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $505,438 | 88,518 | 0.05% | Shares |
| CAPTRUST FINANCIAL ADVISORS | $501,960 | 87,909 | 0.05% | Shares |
| PROFUND ADVISORS LLC | $499,676 | 87,509 | 0.05% | Shares |
| VANGUARD ASSET MANAGEMENT, Ltd | $453,865 | 79,486 | 0.04% | Shares |
| DNB Asset Management AS | $417,669 | 73,147 | 0.04% | Shares |
| Virtus Investment Advisers, LLC | $396,662 | 69,468 | 0.04% | Shares |
| Jain Global LLC | $369,545 | 64,719 | 0.03% | Shares |
| China Universal Asset Management Co., Ltd. | $354,454 | 62,076 | 0.03% | Shares |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $354,437 | 62,073 | 0.03% | Shares |
| DIVERSIFIED TRUST CO | $352,860 | 61,797 | 0.03% | Shares |
| DLD Asset Management, LP | $343,200 | 60,000 | 0.03% | Call option |
| JANUS HENDERSON GROUP PLC | $327,710 | 59,100 | 0.03% | Shares |
| VIRGINIA RETIREMENT SYSTEMS ET Al | $310,053 | 54,300 | 0.03% | Shares |
| WINTON GROUP Ltd | $272,938 | 47,800 | 0.03% | Shares |
| JUPITER ASSET MANAGEMENT LTD | $263,083 | 46,074 | 0.02% | Shares |
| Creative Planning | $262,374 | 45,950 | 0.02% | Shares |
| Police & Firemen's Retirement System of New Jersey | $261,592 | 45,813 | 0.02% | Shares |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $255,272 | 44,706 | 0.02% | Shares |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $254,009 | 44,485 | 0.02% | Shares |
| Allegheny Financial Group | $244,959 | 42,900 | 0.02% | Shares |
| BARCLAYS PLC | $238,193 | 41,715 | 0.02% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $237,062 | 41,517 | 0.02% | Shares |
| State of New Jersey Common Pension Fund D | $225,025 | 39,409 | 0.02% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $224,940 | 39,394 | 0.02% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $224,146 | 39,255 | 0.02% | Shares |
| FIFTH THIRD BANCORP | $220,634 | 38,640 | 0.02% | Shares |
| CANADA PENSION PLAN INVESTMENT BOARD | $220,406 | 38,600 | 0.02% | Shares |
| CWM, LLC | $219,672 | 39,652 | 0.02% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $208,803 | 36,568 | 0.02% | Shares |
| Persistent Asset Partners Ltd | $206,640 | 897 | 0.02% | Call option |
| Vanguard Investments Australia, Ltd. | $200,044 | 35,034 | 0.02% | Shares |
| ARIZONA STATE RETIREMENT SYSTEM | $192,027 | 33,630 | 0.02% | Shares |
| Blueshift Asset Management, LLC | $190,360 | 33,338 | 0.02% | Shares |
| PRELUDE CAPITAL MANAGEMENT, LLC | $180,676 | 31,642 | 0.02% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $176,268 | 30,870 | 0.02% | Shares |
| Lido Advisors, LLC | $176,114 | 30,843 | 0.02% | Shares |
| EntryPoint Capital, LLC | $175,794 | 30,787 | 0.02% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $170,895 | 29,929 | 0.02% | Shares |
| Bridgefront Capital, LLC | $162,895 | 28,528 | 0.02% | Shares |
| COMERICA BANK | $162,432 | 32,357 | 0.02% | Shares |
| Quadrature Capital Ltd | $159,098 | 27,863 | 0.02% | Shares |
| DIADEMA PARTNERS LP | $157,116 | 27,516 | 0.01% | Shares |
| KLP KAPITALFORVALTNING AS | $150,173 | 26,300 | 0.01% | Shares |
| ProShare Advisors LLC | $146,810 | 25,711 | 0.01% | Shares |
| Verdad Advisers, LP | $144,463 | 25,300 | 0.01% | Shares |
| Brevan Howard Capital Management LP | $144,389 | 25,287 | 0.01% | Shares |
| AlphaCentric Advisors LLC | $142,019 | 24,872 | 0.01% | Shares |
| PRUDENTIAL FINANCIAL INC | $141,894 | 24,850 | 0.01% | Shares |
| E Fund Management Co., Ltd. | $139,512 | 24,433 | 0.01% | Shares |
| Crown Wealth Group, LLC | $135,687 | 23,763 | 0.01% | Shares |
| SBI Securities Co., Ltd. | $132,615 | 23,225 | 0.01% | Shares |
| RAYMOND JAMES FINANCIAL INC | $130,582 | 22,869 | 0.01% | Shares |
| STRS OHIO | $121,052 | 21,200 | 0.01% | Shares |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $119,967 | 21,010 | 0.01% | Shares |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | $118,843 | 20,813 | 0.01% | Shares |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $117,467 | 20,253 | 0.01% | Shares |
| Corient Private Wealth LP | $112,510 | 19,704 | 0.01% | Shares |
| State of Wyoming | $111,225 | 19,479 | 0.01% | Shares |
| MERCER GLOBAL ADVISORS INC /ADV | $97,510 | 17,077 | 0.01% | Shares |
| Coastal Bridge Advisors, LLC | $97,070 | 17,000 | 0.01% | Shares |
| Pictet Asset Management Holding SA | $95,363 | 16,701 | 0.01% | Shares |
| Mariner, LLC | $94,053 | 16,469 | 0.01% | Shares |
| LPL Financial LLC | $90,269 | 15,809 | 0.01% | Shares |
| Balefire, LLC | $85,713 | 15,011 | 0.01% | Shares |
| DLD Asset Management, LP | $85,650 | 15,000 | 0.01% | Shares |
| XPONANCE LLC | $84,879 | 14,865 | 0.01% | Shares |
| Forefront Analytics, LLC | $81,310 | 14,240 | 0.01% | Shares |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $81,270 | 14,233 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $80,494 | 14,097 | 0.01% | Shares |
| Private Advisor Group, LLC | $80,054 | 14,020 | 0.01% | Shares |
| Cerity Partners LLC | $79,182 | 13,867 | 0.01% | Shares |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $73,088 | 12,800 | 0.01% | Shares |
| Tower Research Capital LLC (TRC) | $73,008 | 12,786 | 0.01% | Shares |
| Vanguard Personalized Indexing Management, LLC | $71,306 | 12,488 | 0.01% | Shares |
| Quantinno Capital Management LP | $70,022 | 12,263 | 0.01% | Shares |
| Cubist Systematic Strategies, LLC | $69,451 | 22,771 | 0.01% | Shares |
| PRINCIPAL FINANCIAL GROUP INC | $67,812 | 11,876 | 0.01% | Shares |
| Merit Financial Group, LLC | $63,398 | 11,103 | 0.01% | Shares |
| FOX RUN MANAGEMENT, L.L.C. | $62,353 | 10,920 | 0.01% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $61,548 | 10,779 | 0.01% | Shares |
| GROUP ONE TRADING LLC | $57,597 | 10,087 | 0.01% | Shares |
| Harbor Advisors LLC | $57,100 | 10,000 | 0.01% | Shares |
| Shay Capital LLC | $57,100 | 10,000 | 0.01% | Shares |
| JANE STREET GROUP, LLC | $57,100 | 10,000 | 0.01% | Put option |
| Fulcrum Asset Management LLP | $56,090 | 10,070 | 0.01% | Shares |
| Arax Advisory Partners | $43,876 | 7,684 | 0.00% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $41,843 | 7,328 | 0.00% | Shares |
| Persistent Asset Partners Ltd | $38,971 | 6,825 | 0.00% | Shares |
| Geneos Wealth Management Inc. | $34,260 | 6,000 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $31,000 | 5,395 | 0.00% | Shares |
| JONES FINANCIAL COMPANIES LLLP | $19,536 | 3,565 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $17,501 | 3,065 | 0.00% | Shares |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $11,557 | 2,024 | 0.00% | Shares |
| BARCLAYS PLC | $11,420 | 2,000 | 0.00% | Call option |
| Larson Financial Group LLC | $11,420 | 2,000 | 0.00% | Shares |
| Quantbot Technologies LP | $8,919 | 1,562 | 0.00% | Shares |
| PNC Financial Services Group, Inc. | $7,114 | 1,246 | 0.00% | Shares |
| Trask Adam Roland | $5,540 | 1,000 | 0.00% | Shares |
| Allworth Financial LP | $4,774 | 836 | 0.00% | Shares |
| Rockefeller Capital Management L.P. | $4,488 | 786 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $4,185 | 738 | 0.00% | Shares |
| Essential Partners LLC | $3,849 | 674 | 0.00% | Shares |
| ACADIAN ASSET MANAGEMENT LLC | $3,588 | 629,127 | 0.00% | Shares |
| GAMMA Investing LLC | $3,255 | 570 | 0.00% | Shares |
| IFP Advisors, Inc | $3,249 | 569 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $3,191 | 559 | 0.00% | Shares |
| Sterling Capital Management LLC | $3,112 | 545 | 0.00% | Shares |
| Caitong International Asset Management Co., Ltd | $2,838 | 497 | 0.00% | Shares |
| Fortitude Family Office, LLC | $2,758 | 483 | 0.00% | Shares |
| Optiver Holding B.V. | $2,318 | 406 | 0.00% | Shares |
| HighMark Wealth Management LLC | $1,713 | 300 | 0.00% | Shares |
| True Wealth Design, LLC | $1,616 | 283 | 0.00% | Shares |
| Physician Wealth Advisors, Inc. | $1,536 | 269 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $1,422 | 249 | 0.00% | Shares |
| Global Retirement Partners, LLC | $1,034 | 181 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $738 | 129,243 | 0.00% | Shares |
| Sunbelt Securities, Inc. | $609 | 110 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $596 | 104,378 | 0.00% | Shares |
| NATIONAL BANK OF CANADA /FI/ | $383 | 67 | 0.00% | Shares |
| SG Americas Securities, LLC | $245 | 42,823 | 0.00% | Shares |
| CANADA LIFE ASSURANCE Co | $124 | 21,646 | 0.00% | Shares |
| Cygnus Capital Advisors, LLC | $123 | 21,549 | 0.00% | Shares |
| SJS Investment Consulting Inc. | $115 | 20 | 0.00% | Shares |
| Stone House Investment Management, LLC | $91 | 16 | 0.00% | Shares |
| Clearstead Advisors, LLC | $86 | 15 | 0.00% | Shares |
| MOUNT VERNON ASSOCIATES INC /MD/ | $60 | 10,500 | 0.00% | Shares |
| Cambridge Investment Research Advisors, Inc. | $58 | 10,110 | 0.00% | Shares |
| Pacer Advisors, Inc. | $17 | 2,894 | 0.00% | Shares |
| Silver Grove Financial Group, Inc. | $6 | 1 | 0.00% | Shares |