IRON — Institutional owners (13F)
Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.
| Institution | Value | Shares | % of tracked 13F | Type |
|---|---|---|---|---|
| FMR LLC | $357,981,753 | 4,894,473 | 11.37% | Shares |
| BlackRock, Inc. | $180,502,133 | 2,467,899 | 5.73% | Shares |
| RA CAPITAL MANAGEMENT, L.P. | $179,209,164 | 2,450,221 | 5.69% | Shares |
| VANGUARD GROUP INC | $140,371,470 | 1,767,680 | 4.46% | Shares |
| JPMORGAN CHASE & CO | $139,868,053 | 1,875,795 | 4.44% | Shares |
| WELLINGTON MANAGEMENT GROUP LLP | $127,362,413 | 1,741,351 | 4.05% | Shares |
| STATE STREET CORP | $120,595,865 | 1,648,836 | 3.83% | Shares |
| Vestal Point Capital, LP | $113,367,000 | 1,550,000 | 3.60% | Shares |
| Atlas Venture Life Science Advisors, LLC | $110,724,818 | 1,513,875 | 3.52% | Shares |
| VANGUARD CAPITAL MANAGEMENT LLC | $100,130,635 | 1,369,027 | 3.18% | Shares |
| Frazier Life Sciences Management, L.P. | $99,093,875 | 1,354,852 | 3.15% | Shares |
| TCG Crossover Management, LLC | $98,143,787 | 1,341,862 | 3.12% | Shares |
| BVF INC/IL | $84,375,182 | 1,153,612 | 2.68% | Shares |
| Woodline Partners LP | $70,088,672 | 958,281 | 2.23% | Shares |
| Siren, L.L.C. | $64,977,649 | 888,401 | 2.06% | Shares |
| Logos Global Management LP | $63,997,500 | 875,000 | 2.03% | Shares |
| Opaleye Management Inc. | $62,534,700 | 855,000 | 1.99% | Shares |
| GEODE CAPITAL MANAGEMENT, LLC | $57,772,342 | 789,724 | 1.84% | Shares |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $48,052,980 | 657,000 | 1.53% | Shares |
| DIMENSIONAL FUND ADVISORS LP | $41,622,451 | 569,018 | 1.32% | Shares |
| Bellevue Group AG | $40,958,400 | 560,000 | 1.30% | Shares |
| Saturn V Capital Management LP | $38,378,752 | 524,730 | 1.22% | Shares |
| ARMISTICE CAPITAL, LLC | $33,644,400 | 460,000 | 1.07% | Shares |
| JENNISON ASSOCIATES LLC | $32,146,492 | 439,520 | 1.02% | Shares |
| Aberdeen Group plc | $32,048,046 | 438,174 | 1.02% | Shares |
| Palo Alto Investors LP | $30,473,488 | 416,646 | 0.97% | Shares |
| EVENTIDE ASSET MANAGEMENT, LLC | $28,938,480 | 395,651 | 0.92% | Shares |
| Pictet Asset Management Holding SA | $28,186,328 | 385,375 | 0.90% | Shares |
| Assenagon Asset Management S.A. | $28,097,316 | 384,158 | 0.89% | Shares |
| LOOMIS SAYLES & CO L P | $27,929,533 | 381,864 | 0.89% | Shares |
| Foresite Capital Management V, LLC | $27,359,407 | 374,069 | 0.87% | Shares |
| ORBIMED ADVISORS LLC | $26,150,110 | 357,535 | 0.83% | Shares |
| BAKER BROS. ADVISORS LP | $25,573,913 | 349,657 | 0.81% | Shares |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $20,620,872 | 281,937 | 0.66% | Shares |
| Octagon Capital Advisors LP | $19,747,800 | 270,000 | 0.63% | Shares |
| NORTHERN TRUST CORP | $19,381,368 | 264,990 | 0.62% | Shares |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $18,824,919 | 257,382 | 0.60% | Shares |
| Checkpoint Capital L.P. | $17,562,743 | 240,125 | 0.56% | Shares |
| VANGUARD FIDUCIARY TRUST CO | $16,470,982 | 225,198 | 0.52% | Shares |
| CITADEL ADVISORS LLC | $15,308,787 | 209,308 | 0.49% | Shares |
| Bank of New York Mellon Corp | $14,973,763 | 204,727 | 0.48% | Shares |
| BNP PARIBAS FINANCIAL MARKETS | $13,508,592 | 184,695 | 0.43% | Shares |
| Catalio Capital Management, LP | $11,657,346 | 159,384 | 0.37% | Shares |
| Caption Management, LLC | $10,971,000 | 150,000 | 0.35% | Call option |
| Sofinnova Investments, Inc. | $10,695,920 | 146,239 | 0.34% | Shares |
| Bain Capital Life Sciences Investors, LLC | $10,329,855 | 141,234 | 0.33% | Shares |
| TWO SIGMA INVESTMENTS, LP | $10,001,895 | 136,750 | 0.32% | Shares |
| BANK OF AMERICA CORP /DE/ | $9,882,018 | 135,111 | 0.31% | Shares |
| Alyeska Investment Group, L.P. | $9,142,500 | 125,000 | 0.29% | Shares |
| Ensign Peak Advisors, Inc | $8,931,199 | 122,111 | 0.28% | Shares |
| UBS Group AG | $8,116,419 | 110,971 | 0.26% | Shares |
| Trexquant Investment LP | $7,877,105 | 107,699 | 0.25% | Shares |
| KENNEDY CAPITAL MANAGEMENT LLC | $7,809,085 | 106,769 | 0.25% | Shares |
| MILLENNIUM MANAGEMENT LLC | $7,770,979 | 106,248 | 0.25% | Shares |
| GOLDMAN SACHS GROUP INC | $7,122,593 | 97,383 | 0.23% | Shares |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $7,090,307 | 110,890 | 0.23% | Shares |
| MORGAN STANLEY | $6,699,315 | 91,595 | 0.21% | Shares |
| SILVERARC CAPITAL MANAGEMENT, LLC | $6,055,992 | 82,800 | 0.19% | Shares |
| RAYMOND JAMES FINANCIAL INC | $5,703,384 | 77,980 | 0.18% | Shares |
| Squarepoint Ops LLC | $5,549,278 | 75,872 | 0.18% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5,383,104 | 73,600 | 0.17% | Call option |
| DNB Asset Management AS | $5,348,509 | 73,127 | 0.17% | Shares |
| Casdin Capital, LLC | $4,754,100 | 65,000 | 0.15% | Shares |
| SPHERA FUNDS MANAGEMENT LTD. | $4,647,169 | 63,538 | 0.15% | Shares |
| Nuveen, LLC | $4,414,511 | 60,357 | 0.14% | Shares |
| PEAK6 LLC | $4,388,400 | 60,000 | 0.14% | Call option |
| KVP Capital Advisors, LP | $4,260,405 | 58,250 | 0.14% | Shares |
| MOORE CAPITAL MANAGEMENT, LP | $4,227,199 | 57,796 | 0.13% | Shares |
| XTX Topco Ltd | $4,147,769 | 56,710 | 0.13% | Shares |
| NEXTBio Capital Management LP | $3,851,187 | 52,655 | 0.12% | Shares |
| ALGERT GLOBAL LLC | $3,792,309 | 51,850 | 0.12% | Shares |
| ExodusPoint Capital Management, LP | $3,775,706 | 51,623 | 0.12% | Shares |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $3,725,000 | 50,000 | 0.12% | Shares |
| Burkehill Global Management, LP | $3,657,000 | 50,000 | 0.12% | Shares |
| Brevan Howard Capital Management LP | $3,656,707 | 49,996 | 0.12% | Shares |
| Swiss National Bank | $3,642,372 | 49,800 | 0.12% | Shares |
| AMERIPRISE FINANCIAL INC | $3,355,224 | 45,874 | 0.11% | Shares |
| Atle Fund Management AB | $3,194,901 | 43,682 | 0.10% | Shares |
| Quadrature Capital Ltd | $3,102,526 | 42,419 | 0.10% | Shares |
| Invesco Ltd. | $3,076,049 | 42,057 | 0.10% | Shares |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $2,878,790 | 39,360 | 0.09% | Shares |
| ALPS ADVISORS INC | $2,820,644 | 38,565 | 0.09% | Shares |
| CITIGROUP INC | $2,802,506 | 38,317 | 0.09% | Shares |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $2,798,483 | 38,262 | 0.09% | Shares |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $2,679,411 | 36,634 | 0.09% | Shares |
| RHUMBLINE ADVISERS | $2,621,620 | 35,844 | 0.08% | Shares |
| LAZARD ASSET MANAGEMENT LLC | $2,562,387 | 35,034 | 0.08% | Shares |
| SEVEN GRAND MANAGERS, LLC | $2,559,900 | 35,000 | 0.08% | Shares |
| MARSHALL WACE, LLP | $2,515,577 | 34,394 | 0.08% | Shares |
| Jump Financial, LLC | $2,380,634 | 32,549 | 0.08% | Shares |
| BANK OF MONTREAL /CAN/ | $2,363,007 | 32,308 | 0.08% | Shares |
| DEUTSCHE BANK AG\ | $2,241,229 | 30,643 | 0.07% | Shares |
| ALLIANCEBERNSTEIN L.P. | $2,216,800 | 34,670 | 0.07% | Shares |
| RTW INVESTMENTS, LP | $2,194,200 | 30,000 | 0.07% | Shares |
| Squadron Capital Management LLC | $2,194,200 | 30,000 | 0.07% | Call option |
| VICTORY CAPITAL MANAGEMENT INC | $2,129,618 | 29,117 | 0.07% | Shares |
| WELLS FARGO & COMPANY/MN | $2,115,464 | 28,924 | 0.07% | Shares |
| TUDOR INVESTMENT CORP ET AL | $2,096,412 | 28,663 | 0.07% | Shares |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $2,031,171 | 27,771 | 0.06% | Shares |
| Y-Intercept (Hong Kong) Ltd | $1,966,588 | 26,888 | 0.06% | Shares |
| Rafferty Asset Management, LLC | $1,943,037 | 26,566 | 0.06% | Shares |
| Campbell & CO Investment Adviser LLC | $1,870,044 | 25,568 | 0.06% | Shares |
| PNC Financial Services Group, Inc. | $1,633,435 | 22,333 | 0.05% | Shares |
| TD Asset Management Inc | $1,579,824 | 21,600 | 0.05% | Shares |
| Engineers Gate Manager LP | $1,430,033 | 19,552 | 0.05% | Shares |
| BARCLAYS PLC | $1,368,450 | 18,710 | 0.04% | Shares |
| Legal & General Group Plc | $1,350,019 | 18,458 | 0.04% | Shares |
| DLD Asset Management, LP | $1,330,238 | 18,200 | 0.04% | Put option |
| CITADEL ADVISORS LLC | $1,258,008 | 17,200 | 0.04% | Put option |
| MetLife Investment Management, LLC | $1,213,246 | 16,588 | 0.04% | Shares |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $1,182,775 | 16,114 | 0.04% | Shares |
| VANGUARD ASSET MANAGEMENT, Ltd | $1,178,359 | 16,111 | 0.04% | Shares |
| JANE STREET GROUP, LLC | $1,171,045 | 16,011 | 0.04% | Shares |
| CITADEL ADVISORS LLC | $1,155,612 | 15,800 | 0.04% | Call option |
| STATE OF WISCONSIN INVESTMENT BOARD | $1,128,477 | 15,429 | 0.04% | Shares |
| Man Group plc | $1,091,615 | 14,925 | 0.03% | Shares |
| HighVista Strategies LLC | $1,039,978 | 14,219 | 0.03% | Shares |
| PROFUND ADVISORS LLC | $988,048 | 13,509 | 0.03% | Shares |
| Ikarian Capital, LLC | $972,762 | 13,300 | 0.03% | Call option |
| Ikarian Capital, LLC | $972,762 | 13,300 | 0.03% | Put option |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $948,699 | 12,971 | 0.03% | Shares |
| Qube Research & Technologies Ltd | $933,120 | 12,758 | 0.03% | Shares |
| SEI INVESTMENTS CO | $925,008 | 12,647 | 0.03% | Shares |
| MARTINGALE ASSET MANAGEMENT L P | $878,339 | 12,009 | 0.03% | Shares |
| Vanguard Global Advisers, LLC | $848,205 | 11,597 | 0.03% | Shares |
| JANUS HENDERSON GROUP PLC | $739,462 | 11,555 | 0.02% | Shares |
| NEW YORK STATE COMMON RETIREMENT FUND | $736,959 | 10,076 | 0.02% | Shares |
| AQR CAPITAL MANAGEMENT LLC | $721,745 | 9,868 | 0.02% | Shares |
| JANE STREET GROUP, LLC | $665,574 | 9,100 | 0.02% | Call option |
| Entropy Technologies, LP | $614,961 | 8,408 | 0.02% | Shares |
| Police & Firemen's Retirement System of New Jersey | $610,353 | 8,345 | 0.02% | Shares |
| China Universal Asset Management Co., Ltd. | $602,600 | 8,239 | 0.02% | Shares |
| Lion Point Capital, LP | $592,434 | 8,100 | 0.02% | Shares |
| Russell Investments Group, Ltd. | $591,190 | 8,083 | 0.02% | Shares |
| State of New Jersey Common Pension Fund D | $586,583 | 8,020 | 0.02% | Shares |
| PSP Research LLC | $585,120 | 8,000 | 0.02% | Shares |
| Cubist Systematic Strategies, LLC | $575,848 | 8,714 | 0.02% | Shares |
| Quantinno Capital Management LP | $533,703 | 7,297 | 0.02% | Shares |
| JANE STREET GROUP, LLC | $526,608 | 7,200 | 0.02% | Put option |
| ARIZONA STATE RETIREMENT SYSTEM | $500,570 | 6,844 | 0.02% | Shares |
| EntryPoint Capital, LLC | $465,975 | 6,371 | 0.01% | Shares |
| SummitTX Capital, L.P. | $461,440 | 6,309 | 0.01% | Shares |
| Creative Planning | $457,418 | 6,254 | 0.01% | Shares |
| INTECH INVESTMENT MANAGEMENT LLC | $442,790 | 6,054 | 0.01% | Shares |
| AXQ CAPITAL, LP | $441,400 | 6,035 | 0.01% | Shares |
| D. E. Shaw & Co., Inc. | $440,815 | 6,027 | 0.01% | Shares |
| Vanguard Investments Australia, Ltd. | $435,841 | 5,959 | 0.01% | Shares |
| Susquehanna Portfolio Strategies, LLC | $424,797 | 5,808 | 0.01% | Shares |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $412,510 | 5,640 | 0.01% | Shares |
| VOYA INVESTMENT MANAGEMENT LLC | $397,150 | 5,430 | 0.01% | Shares |
| KLP KAPITALFORVALTNING AS | $380,328 | 5,200 | 0.01% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $365,700 | 5,000 | 0.01% | Put option |
| ProShare Advisors LLC | $362,701 | 4,959 | 0.01% | Shares |
| Virtus Investment Advisers, LLC | $351,950 | 4,812 | 0.01% | Shares |
| JONES FINANCIAL COMPANIES LLLP | $345,184 | 4,616 | 0.01% | Shares |
| PRUDENTIAL FINANCIAL INC | $338,638 | 4,630 | 0.01% | Shares |
| Eleva Capital SAS | $327,053 | 5,115 | 0.01% | Shares |
| Fiduciary Trust Co | $296,290 | 4,051 | 0.01% | Shares |
| AlphaCentric Advisors LLC | $294,754 | 4,030 | 0.01% | Shares |
| BOOTHBAY FUND MANAGEMENT, LLC | $292,560 | 4,000 | 0.01% | Call option |
| BOOTHBAY FUND MANAGEMENT, LLC | $292,560 | 4,000 | 0.01% | Put option |
| E Fund Management Co., Ltd. | $273,982 | 3,746 | 0.01% | Shares |
| Bryce Point Capital, LLC | $258,505 | 3,912 | 0.01% | Shares |
| CAPSTONE INVESTMENT ADVISORS, LLC | $245,385 | 3,355 | 0.01% | Shares |
| Jain Global LLC | $228,928 | 3,130 | 0.01% | Shares |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $225,417 | 3,082 | 0.01% | Shares |
| DLD Asset Management, LP | $219,420 | 3,000 | 0.01% | Shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $213,130 | 2,914 | 0.01% | Shares |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $211,741 | 2,895 | 0.01% | Shares |
| STRS OHIO | $197,478 | 2,700 | 0.01% | Shares |
| Ameritas Investment Partners, Inc. | $187,824 | 2,568 | 0.01% | Shares |
| Quantbot Technologies LP | $152,863 | 2,090 | 0.00% | Shares |
| PRICE T ROWE ASSOCIATES INC /MD/ | $137,168 | 1,875,399 | 0.00% | Shares |
| Mirae Asset Global Investments Co., Ltd. | $124,923 | 1,708 | 0.00% | Shares |
| US BANCORP \DE\ | $89,889 | 1,229 | 0.00% | Shares |
| ROYAL BANK OF CANADA | $73,000 | 989 | 0.00% | Shares |
| Foresite Capital Management VI LLC | $70,946 | 970 | 0.00% | Shares |
| Tower Research Capital LLC (TRC) | $68,678 | 939 | 0.00% | Shares |
| CWM, LLC | $66,178 | 1,035 | 0.00% | Shares |
| GF FUND MANAGEMENT CO. LTD. | $59,170 | 809 | 0.00% | Shares |
| Allworth Financial LP | $46,298 | 633 | 0.00% | Shares |
| NISA INVESTMENT ADVISORS, LLC | $41,397 | 566 | 0.00% | Shares |
| Steward Partners Investment Advisory, LLC | $38,618 | 528 | 0.00% | Shares |
| Bayforest Capital Ltd | $32,986 | 451 | 0.00% | Shares |
| AlphaQuest LLC | $29,064 | 366 | 0.00% | Shares |
| State of Wyoming | $25,306 | 346 | 0.00% | Shares |
| GAMMA Investing LLC | $21,357 | 292 | 0.00% | Shares |
| Kemnay Advisory Services Inc. | $19,675 | 269 | 0.00% | Shares |
| OSAIC HOLDINGS, INC. | $19,602 | 268 | 0.00% | Shares |
| TORONTO DOMINION BANK | $14,482 | 198 | 0.00% | Shares |
| J.Safra Asset Management Corp | $11,776 | 161 | 0.00% | Shares |
| Larson Financial Group LLC | $8,996 | 123 | 0.00% | Shares |
| Sterling Capital Management LLC | $7,241 | 99 | 0.00% | Shares |
| Smartleaf Asset Management LLC | $6,854 | 92 | 0.00% | Shares |
| HRT FINANCIAL LP | $6,642 | 90,822 | 0.00% | Shares |
| Arax Advisory Partners | $6,290 | 86 | 0.00% | Shares |
| CoreCap Advisors, LLC | $5,705 | 78 | 0.00% | Shares |
| iA Global Asset Management Inc. | $4,829 | 66,023 | 0.00% | Shares |
| Optiver Holding B.V. | $4,754 | 65 | 0.00% | Shares |
| Farther Finance Advisors, LLC | $3,439 | 47 | 0.00% | Shares |
| Versant Capital Management, Inc | $3,273 | 50 | 0.00% | Shares |
| Lindbrook Capital, LLC | $2,879 | 58 | 0.00% | Shares |
| FIRST HORIZON CORP | $2,633 | 36 | 0.00% | Shares |
| ROTHSCHILD INVESTMENT LLC | $2,340 | 32 | 0.00% | Shares |
| Silver Grove Financial Group, Inc. | $1,902 | 26 | 0.00% | Shares |
| FIFTH THIRD BANCORP | $1,844 | 25 | 0.00% | Shares |
| COMERICA BANK | $1,544 | 19 | 0.00% | Shares |
| Parkside Financial Bank & Trust | $1,462 | 20 | 0.00% | Shares |
| Quarry LP | $1,317 | 18 | 0.00% | Shares |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $1,287 | 17,599 | 0.00% | Shares |
| JPL Wealth Management, LLC | $1,244 | 17 | 0.00% | Shares |
| EverSource Wealth Advisors, LLC | $1,243 | 17 | 0.00% | Shares |
| GSA CAPITAL PARTNERS LLP | $1,194 | 16,324 | 0.00% | Shares |
| Geneos Wealth Management Inc. | $951 | 13 | 0.00% | Shares |
| HUNTINGTON NATIONAL BANK | $878 | 12 | 0.00% | Shares |
| ASSETMARK, INC | $878 | 12 | 0.00% | Shares |
| Cornerstone Financial Management LLC | $805 | 11 | 0.00% | Shares |
| Bare Financial Services, Inc | $658 | 9 | 0.00% | Shares |
| SG Americas Securities, LLC | $563 | 7,704 | 0.00% | Shares |
| Keating Financial Advisory Services, Inc. | $439 | 6 | 0.00% | Shares |
| Essential Partners LLC | $366 | 5 | 0.00% | Shares |
| Virtu Financial LLC | $343 | 4,694 | 0.00% | Shares |
| Global Retirement Partners, LLC | $293 | 4 | 0.00% | Shares |
| Clearstead Advisors, LLC | $148 | 2 | 0.00% | Shares |
| Hughes Financial Services, LLC | $146 | 2 | 0.00% | Shares |
| Downshift Financial, LLC | $146 | 2 | 0.00% | Shares |
| KBC Group NV | $74 | 1,011 | 0.00% | Shares |
| Fortitude Family Office, LLC | $73 | 1 | 0.00% | Shares |
| Wealth Enhancement Trust Services, Inc. | $73 | 1 | 0.00% | Shares |
| SBI Securities Co., Ltd. | $73 | 1 | 0.00% | Shares |
| IFP Advisors, Inc | $73 | 1 | 0.00% | Shares |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | $53 | 730 | 0.00% | Shares |
| Pacer Advisors, Inc. | $32 | 444 | 0.00% | Shares |
| Covestor Ltd | $1 | 7 | 0.00% | Shares |
| GW&K Investment Management, LLC | $1 | 16 | 0.00% | Shares |