AGIO — Institutional owners (13F)

262 filers · $2.7B total · As of Sept. 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institution Value Shares % of tracked 13F Type
BlackRock, Inc. $239,582,050 6,455,997 8.88% Shares
FARALLON CAPITAL MANAGEMENT, L.L.C. $219,594,714 5,917,400 8.14% Shares
VANGUARD GROUP INC $152,278,288 5,594,353 5.64% Shares
STATE STREET CORP $131,144,972 3,533,633 4.86% Shares
Lynx1 Capital Management LP $126,505,652 3,408,937 4.69% Shares
D. E. Shaw & Co., Inc. $115,300,956 3,107,005 4.27% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $107,552,091 2,898,197 3.98% Shares
ARMISTICE CAPITAL, LLC $104,279,100 2,810,000 3.86% Call option
VANGUARD CAPITAL MANAGEMENT LLC $99,523,268 2,681,845 3.69% Shares
ARMISTICE CAPITAL, LLC $89,064,000 2,400,000 3.30% Shares
Erste Asset Management GmbH $81,972,396 2,154,900 3.04% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $78,332,000 2,110,809 2.90% Shares
GEODE CAPITAL MANAGEMENT, LLC $58,433,490 1,574,268 2.17% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $51,046,957 1,375,558 1.89% Shares
ADAR1 Capital Management, LLC $47,799,647 1,288,053 1.77% Shares
BNP PARIBAS ASSET MANAGEMENT Holding S.A. $47,502,433 1,280,044 1.76% Shares
DIMENSIONAL FUND ADVISORS LP $46,345,467 1,248,738 1.72% Shares
GOLDMAN SACHS GROUP INC $42,711,087 1,150,932 1.58% Shares
UBS Group AG $36,584,189 985,831 1.36% Shares
MORGAN STANLEY $35,746,487 963,256 1.32% Shares
Nuveen, LLC $32,417,811 873,560 1.20% Shares
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $30,078,768 810,530 1.11% Shares
Foresite Capital Management VI LLC $29,131,350 785,000 1.08% Shares
CITADEL ADVISORS LLC $27,190,015 732,687 1.01% Shares
AQR CAPITAL MANAGEMENT LLC $25,395,858 684,340 0.94% Shares
Parkman Healthcare Partners LLC $24,828,297 669,046 0.92% Shares
SCS Capital Management LLC $22,742,864 612,850 0.84% Shares
Qube Research & Technologies Ltd $22,178,346 597,638 0.82% Shares
NORTHERN TRUST CORP $20,585,250 554,709 0.76% Shares
Defilade Capital Management, L.P. $20,293,529 546,848 0.75% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $19,969,930 538,128 0.74% Shares
TWO SIGMA INVESTMENTS, LP $19,905,062 536,380 0.74% Shares
Rock Springs Capital Management LP $19,763,413 532,563 0.73% Shares
Schonfeld Strategic Advisors LLC $19,300,279 520,083 0.72% Shares
BANK OF AMERICA CORP /DE/ $18,847,034 507,869 0.70% Shares
Point72 Asset Management, L.P. $18,790,426 506,344 0.70% Shares
JANE STREET GROUP, LLC $18,280,312 492,598 0.68% Shares
Legal & General Group Plc $16,132,422 434,719 0.60% Shares
VANGUARD FIDUCIARY TRUST CO $14,690,661 395,868 0.54% Shares
PANAGORA ASSET MANAGEMENT INC $13,876,579 373,931 0.51% Shares
KENNEDY CAPITAL MANAGEMENT LLC $13,850,565 373,230 0.51% Shares
JPMORGAN CHASE & CO $13,783,528 359,756 0.51% Shares
Connor, Clark & Lunn Investment Management Ltd. $13,342,901 359,550 0.49% Shares
Squarepoint Ops LLC $11,917,431 321,138 0.44% Shares
Ensign Peak Advisors, Inc $11,045,049 297,630 0.41% Shares
BNP PARIBAS FINANCIAL MARKETS $9,996,803 269,383 0.37% Shares
ALGERT GLOBAL LLC $9,203,540 248,007 0.34% Shares
JANE STREET GROUP, LLC $7,974,939 214,900 0.30% Put option
Palo Alto Investors LP $7,926,733 213,601 0.29% Shares
Tetragon Partners GP Ltd $7,629,037 205,579 0.28% Shares
Bank of New York Mellon Corp $7,373,215 198,685 0.27% Shares
AXA Investment Managers S.A. $7,131,875 177,675 0.26% Shares
Cutter Capital Management, LP $6,895,755 235,350 0.26% Shares
Jump Financial, LLC $6,782,706 182,773 0.25% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $6,334,677 170,700 0.23% Call option
Invesco Ltd. $6,240,157 168,153 0.23% Shares
FIRST TRUST ADVISORS LP $6,144,933 165,587 0.23% Shares
Ishara Investments LP $6,086,040 164,000 0.23% Shares
GROUP ONE TRADING LLC $5,640,497 151,994 0.21% Shares
BOOTHBAY FUND MANAGEMENT, LLC $5,562,269 149,886 0.21% Shares
MARSHALL WACE, LLP $5,150,868 138,800 0.19% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $5,080,359 136,900 0.19% Put option
AMERICAN CENTURY COMPANIES INC $4,991,740 134,512 0.18% Shares
Man Group plc $4,618,933 124,466 0.17% Shares
ArrowMark Colorado Holdings LLC $4,368,367 117,714 0.16% Shares
Pictet Asset Management Holding SA $4,247,606 111,861 0.16% Shares
Swiss National Bank $4,143,703 111,660 0.15% Shares
CAPITAL FUND MANAGEMENT S.A. $3,862,408 104,080 0.14% Shares
Assenagon Asset Management S.A. $3,857,770 103,955 0.14% Shares
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC $3,744,272 110,679 0.14% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $3,700,831 99,726 0.14% Shares
Knott David M Jr $3,527,602 95,058 0.13% Shares
Trexquant Investment LP $3,471,232 93,539 0.13% Shares
CITADEL ADVISORS LLC $3,402,987 91,700 0.13% Call option
Jain Global LLC $3,401,020 91,647 0.13% Shares
Caligan Partners LP $3,339,900 90,000 0.12% Call option
CITIGROUP INC $3,308,987 89,167 0.12% Shares
CITADEL ADVISORS LLC $3,295,368 88,800 0.12% Put option
RHUMBLINE ADVISERS $2,948,045 79,441 0.11% Shares
Campbell & CO Investment Adviser LLC $2,712,555 73,095 0.10% Shares
Exome Asset Management LLC $2,616,255 70,500 0.10% Shares
Edgestream Partners, L.P. $2,604,936 70,195 0.10% Shares
Russell Investments Group, Ltd. $2,481,023 66,856 0.09% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $2,478,800 66,796 0.09% Shares
TUDOR INVESTMENT CORP ET AL $2,441,059 65,779 0.09% Shares
TWO SIGMA ADVISERS, LP $2,319,144 85,200 0.09% Shares
DEUTSCHE BANK AG\ $2,309,281 62,228 0.09% Shares
ALPS ADVISORS INC $2,228,789 60,059 0.08% Shares
Seven Fleet Capital Management LP $2,111,559 56,900 0.08% Shares
ALLIANCEBERNSTEIN L.P. $2,092,859 61,864 0.08% Shares
Rafferty Asset Management, LLC $2,062,574 55,580 0.08% Shares
Engineers Gate Manager LP $2,000,674 53,912 0.07% Shares
WELLS FARGO & COMPANY/MN $1,975,736 53,240 0.07% Shares
VANGUARD ASSET MANAGEMENT, Ltd $1,931,576 52,050 0.07% Shares
XTX Topco Ltd $1,869,082 50,366 0.07% Shares
Caption Management, LLC $1,855,500 50,000 0.07% Call option
Tetragon Partners GP Ltd $1,855,500 50,000 0.07% Call option
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main $1,846,742 49,764 0.07% Shares
BARCLAYS PLC $1,792,412 48,300 0.07% Shares
Quantinno Capital Management LP $1,614,805 43,514 0.06% Shares
MARTINGALE ASSET MANAGEMENT L P $1,596,064 43,009 0.06% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $1,544,400 41,455 0.06% Shares
IEQ CAPITAL, LLC $1,499,392 40,404 0.06% Shares
Kodai Capital Management LP $1,485,276 50,692 0.06% Shares
Virtus Investment Advisers, LLC $1,464,843 39,473 0.05% Shares
Caption Management, LLC $1,456,530 39,249 0.05% Shares
JANE STREET GROUP, LLC $1,451,001 39,100 0.05% Call option
FMR LLC $1,449,962 39,072 0.05% Shares
Aquatic Capital Management LLC $1,433,448 38,627 0.05% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $1,400,049 37,727 0.05% Shares
SEI INVESTMENTS CO $1,302,150 35,089 0.05% Shares
EDGEWOOD MANAGEMENT LLC $1,298,850 35,000 0.05% Shares
MetLife Investment Management, LLC $1,279,182 34,470 0.05% Shares
CITIGROUP INC $1,224,630 33,000 0.05% Call option
CITIGROUP INC $1,224,630 33,000 0.05% Put option
STATE OF WISCONSIN INVESTMENT BOARD $1,196,241 32,235 0.04% Shares
Bridgefront Capital, LLC $1,154,010 31,097 0.04% Shares
Mariner, LLC $1,081,528 29,139 0.04% Shares
PROFUND ADVISORS LLC $1,048,729 28,260 0.04% Shares
Quadrature Capital Ltd $1,043,199 28,111 0.04% Shares
VIRGINIA RETIREMENT SYSTEMS ET Al $1,030,211 27,761 0.04% Shares
AXQ CAPITAL, LP $1,026,314 27,656 0.04% Shares
OAK RIDGE INVESTMENTS LLC $951,834 25,649 0.04% Shares
BOOTHBAY FUND MANAGEMENT, LLC $950,016 25,600 0.04% Call option
Coppell Advisory Solutions LLC $909,940 59 0.03% Shares
DIVERSIFIED TRUST CO $888,710 23,948 0.03% Shares
Zurcher Kantonalbank (Zurich Cantonalbank) $876,538 23,620 0.03% Shares
Vanguard Global Advisers, LLC $865,294 23,317 0.03% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $851,229 22,938 0.03% Shares
CenterBook Partners LP $812,152 21,885 0.03% Shares
JANUS HENDERSON GROUP PLC $804,696 23,797 0.03% Shares
Creative Planning $801,724 21,604 0.03% Shares
MERCER GLOBAL ADVISORS INC /ADV $790,257 21,295 0.03% Shares
WELLINGTON MANAGEMENT GROUP LLP $774,671 20,875 0.03% Shares
Headlands Technologies LLC $772,074 20,805 0.03% Shares
NEW YORK STATE COMMON RETIREMENT FUND $770,700 20,768 0.03% Shares
Cerity Partners LLC $750,699 20,229 0.03% Shares
Quarry LP $747,655 20,147 0.03% Shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC $740,450 17,959 0.03% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $669,020 18,028 0.02% Shares
State of New Jersey Common Pension Fund D $667,906 17,998 0.02% Shares
Police & Firemen's Retirement System of New Jersey $647,347 17,444 0.02% Shares
CANADA PENSION PLAN INVESTMENT BOARD $612,315 16,500 0.02% Shares
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM $588,082 15,847 0.02% Shares
FOX RUN MANAGEMENT, L.L.C. $579,732 15,622 0.02% Shares
ARIZONA STATE RETIREMENT SYSTEM $569,972 15,359 0.02% Shares
TD Asset Management Inc $559,841 15,086 0.02% Shares
Rockefeller Capital Management L.P. $554,238 14,935 0.02% Shares
AlphaCentric Advisors LLC $525,960 14,173 0.02% Shares
Atria Investments, Inc $520,765 14,033 0.02% Shares
Vanguard Investments Australia, Ltd. $502,358 13,537 0.02% Shares
Inspire Investing, LLC $498,654 14,740 0.02% Shares
INTECH INVESTMENT MANAGEMENT LLC $477,160 12,858 0.02% Shares
COMMERCE BANK $461,538 12,437 0.02% Shares
WOLVERINE TRADING, LLC $447,678 11,400 0.02% Call option
ENVESTNET ASSET MANAGEMENT INC $447,435 12,057 0.02% Shares
KLP KAPITALFORVALTNING AS $437,898 11,800 0.02% Shares
CAPTRUST FINANCIAL ADVISORS $421,236 11,351 0.02% Shares
VOYA INVESTMENT MANAGEMENT LLC $421,199 11,350 0.02% Shares
Gallagher Fiduciary Advisors, LLC $411,717 11,095 0.02% Shares
ROYAL BANK OF CANADA $388,000 10,429 0.01% Shares
Toroso Investments, LLC $387,803 14,247 0.01% Shares
PRUDENTIAL FINANCIAL INC $369,430 9,955 0.01% Shares
Hudson Bay Capital Management LP $359,967 9,700 0.01% Shares
ProShare Advisors LLC $359,745 9,694 0.01% Shares
ALLSTATE CORP $351,988 9,485 0.01% Shares
China Universal Asset Management Co., Ltd. $351,246 9,465 0.01% Shares
Brevan Howard Capital Management LP $344,752 9,290 0.01% Shares
CAPSTONE INVESTMENT ADVISORS, LLC $341,264 9,196 0.01% Shares
AlphaQuest LLC $325,633 11,963 0.01% Shares
Fiduciary Trust Co $306,158 8,250 0.01% Shares
HSBC HOLDINGS PLC $293,014 7,717 0.01% Shares
E Fund Management Co., Ltd. $290,831 7,837 0.01% Shares
JONES FINANCIAL COMPANIES LLLP $289,101 7,628 0.01% Shares
Financiere des Professionnels - Fonds d'investissement inc. $278,511 7,505 0.01% Shares
PDT Partners, LLC $278,325 7,500 0.01% Shares
Savvy Advisors, Inc. $252,125 6,794 0.01% Shares
Cubist Systematic Strategies, LLC $251,438 6,264 0.01% Shares
TEACHER RETIREMENT SYSTEM OF TEXAS $240,287 6,475 0.01% Shares
VICTORY CAPITAL MANAGEMENT INC $239,026 6,441 0.01% Shares
Vanguard Personalized Indexing Management, LLC $229,043 6,172 0.01% Shares
PNC Financial Services Group, Inc. $216,573 5,836 0.01% Shares
XPONANCE LLC $213,642 5,757 0.01% Shares
Merit Financial Group, LLC $206,183 5,556 0.01% Shares
Inscription Capital, LLC $205,589 5,540 0.01% Shares
Arax Advisory Partners $199,504 5,376 0.01% Shares
Ameritas Investment Partners, Inc. $199,206 5,368 0.01% Shares
Eurizon Capital SGR S.p.A. $100,784 2,647 0.00% Shares
Mirae Asset Global Investments Co., Ltd. $98,713 2,660 0.00% Shares
Tower Research Capital LLC (TRC) $76,224 2,054 0.00% Shares
Allworth Financial LP $73,144 1,971 0.00% Shares
Versant Capital Management, Inc $66,533 2,001 0.00% Shares
OSAIC HOLDINGS, INC. $59,079 1,592 0.00% Shares
Bayforest Capital Ltd $55,368 1,492 0.00% Shares
NISA INVESTMENT ADVISORS, LLC $50,395 1,358 0.00% Shares
ASSETMARK, INC $48,874 1,317 0.00% Shares
GF FUND MANAGEMENT CO. LTD. $46,091 1,242 0.00% Shares
GW&K Investment Management, LLC $44,777 1,206,615 0.00% Shares
Quantbot Technologies LP $43,493 1,172 0.00% Shares
CWM, LLC $43,336 1,281 0.00% Shares
Sterling Capital Management LLC $42,157 1,136 0.00% Shares
Essential Partners LLC $20,670 557 0.00% Shares
US BANCORP \DE\ $20,114 542 0.00% Shares
GAMMA Investing LLC $19,965 538 0.00% Shares
EverSource Wealth Advisors, LLC $19,855 535 0.00% Shares
Kemnay Advisory Services Inc. $19,780 533 0.00% Shares
Farther Finance Advisors, LLC $18,077 484 0.00% Shares
FTB Advisors, Inc. $17,395 523 0.00% Shares
CITY HOLDING CO $16,910 500 0.00% Shares
Smartleaf Asset Management LLC $16,129 424 0.00% Shares
ROTHSCHILD INVESTMENT LLC $14,918 402 0.00% Shares
SIGNATUREFD, LLC $14,807 399 0.00% Shares
FIRST HORIZON CORP $13,174 355 0.00% Shares
True Wealth Design, LLC $11,356 306 0.00% Shares
FIFTH THIRD BANCORP $10,447 281 0.00% Shares
THURSTON, SPRINGER, MILLER, HERD & TITAK, INC. $8,943 241 0.00% Shares
Bell Investment Advisors, Inc $8,796 237 0.00% Shares
IFP Advisors, Inc $8,647 233 0.00% Shares
PRICE T ROWE ASSOCIATES INC /MD/ $8,127 218,966 0.00% Shares
Lindbrook Capital, LLC $7,530 257 0.00% Shares
Concord Wealth Partners $7,422 200 0.00% Shares
Hillsdale Investment Management Inc. $7,422 200 0.00% Shares
HRT FINANCIAL LP $5,965 160,759 0.00% Shares
COMERICA BANK $5,703 209 0.00% Shares
SJS Investment Consulting Inc. $4,862 131 0.00% Shares
Keating Financial Advisory Services, Inc. $4,602 124 0.00% Shares
Hurley Capital, LLC $4,453 120 0.00% Shares
Triumph Capital Management $3,711 100 0.00% Shares
Private Wealth Management Group, LLC $3,081 83 0.00% Shares
JPL Wealth Management, LLC $2,970 80 0.00% Shares
Wealth Enhancement Trust Services, Inc. $2,857 77 0.00% Shares
Larson Financial Group LLC $2,449 66 0.00% Shares
Clearstead Advisors, LLC $2,339 63 0.00% Shares
HARBOR CAPITAL ADVISORS, INC. $1,727 46,550 0.00% Shares
Pinnacle Wealth Planning Services, Inc. $1,484 40 0.00% Shares
ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ $1,410 38 0.00% Shares
SG Americas Securities, LLC $1,275 34,348 0.00% Shares
SBI Securities Co., Ltd. $1,188 32 0.00% Shares
GSA CAPITAL PARTNERS LLP $932 25,113 0.00% Shares
Parkside Financial Bank & Trust $817 22 0.00% Shares
Parallel Advisors, LLC $742 20 0.00% Shares
FEDERATED HERMES, INC. $705 19 0.00% Shares
Handelsbanken Fonder AB $654 19,323 0.00% Shares
CANADA LIFE ASSURANCE Co $634 17,121 0.00% Shares
Manchester Capital Management LLC $594 16 0.00% Shares
Global Retirement Partners, LLC $408 11 0.00% Shares
Steward Partners Investment Advisory, LLC $334 9 0.00% Shares
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO $252 6,796 0.00% Shares
FIDUCIARY FINANCIAL ADVISORS $185 5 0.00% Shares
State of Alaska, Department of Revenue $185 5,000 0.00% Shares
KBC Group NV $77 2,073 0.00% Shares
Fortitude Family Office, LLC $74 2 0.00% Shares
Bay Harbor Wealth Management, LLC $74 2 0.00% Shares
JFS WEALTH ADVISORS, LLC $68 2 0.00% Shares
Dunhill Financial, LLC $67 1 0.00% Shares
Rialto Wealth Management, LLC $38 1 0.00% Shares
Hughes Financial Services, LLC $37 1 0.00% Shares
Pacer Advisors, Inc. $34 928 0.00% Shares
ACADIAN ASSET MANAGEMENT LLC $31 876 0.00% Shares
BESSEMER GROUP INC $3 76 0.00% Shares
Covestor Ltd $0 12 0.00% Shares
Hemington Wealth Management $0 15 0.00% Shares