Performance vs S&P 500

03
Tracked Q1 2025–Q2 2026 +145.0%
S&P 500 total return (same window) +37.0%
Excess return +108.0%

Annualized: +104.9% · S&P 500: +28.7%

Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.

Priceable coverage: 95.8% · Options excluded: 7.1%

Sector breakdown

04
Healthcare 98.9%
Other/Unmapped 1.1%

Full portfolio 52 positions

05
Type Streak 8Q trend
GH Guardant Health, Inc. - Common Stock $10,127,025 6.25% 67,500 $2,484,701 Down ×2
PRAX Praxis Precision Medicines, Inc. - Common Stock $9,107,962 5.62% 27,205 $-5,541,695 Down ×3
TGTX TG Therapeutics, Inc. - Common Stock $9,060,430 5.59% 164,915 Up ×1
COGT Cogent Biosciences, Inc. - Common Stock $8,147,240 5.03% 210,523 $-2,573,495 Down ×5
IONS Ionis Pharmaceuticals, Inc. - Common Stock $6,991,554 4.31% 88,177 $-1,273,152 Down ×3
LLY Eli Lilly and Company Common Stock $6,587,270 4.06% 5,492 $137,843 Down ×2
ABVX Abivax SA - American Depositary Shares $6,246,962 3.85% 46,878 Up ×1
ALMS Alumis Inc. - Common Stock $5,752,323 3.55% 204,418 $-397,924 Down ×3
CYTK Cytokinetics, Incorporated - Common Stock $5,116,171 3.16% 60,056 $-1,719,882 Down ×3
ELVN Enliven Therapeutics, Inc. - Common Stock $5,085,302 3.14% 100,203 $-3,542,265 Down ×2
VERA Vera Therapeutics, Inc. - Class A Common Stock $4,174,113 2.57% 97,276 $-451,975 Down ×3
UNH UnitedHealth Group Incorporated Common Stock (DE) $3,995,036 2.46% 9,612 $514,707 Down ×1
TXG 10x Genomics, Inc. - Common Stock $3,934,796 2.43% 102,629 $661,257 Down ×2
NTRA Natera, Inc. - Common Stock $3,746,010 2.31% 13,800 $16,196 Down ×1
QURE uniQure N.V. - Ordinary Shares $3,733,439 2.30% 81,056
RYTM Rhythm Pharmaceuticals, Inc. - Common Stock $3,576,165 2.21% 32,209 $46,835 Down ×1
MAZE Maze Therapeutics, Inc. - Common Stock $3,422,409 2.11% 114,692 $780,385 Up ×1
GLUE Monte Rosa Therapeutics, Inc. - Common Stock $3,318,183 2.05% 137,115 $365,671 Down ×1
MLTX MoonLake Immunotherapeutics - Class A Ordinary Shares $3,241,619 2.00% 166,493 $-772,990 Down ×1
ALKS Alkermes plc - Ordinary Shares $3,213,700 1.98% 61,336 $239,818 Down ×1
LQDA Liquidia Corporation - Common Stock $3,127,330 1.93% 39,224 $1,398,989 Down ×3
UTHR United Therapeutics Corporation - Common Stock $2,931,300 1.81% 5,410 $-1,250,988 Down ×2
GKOS Glaukos Corporation Common Stock $2,775,913 1.71% 19,862 $528,618 Down ×2
ARWR Arrowhead Pharmaceuticals, Inc. - Common Stock $2,625,763 1.62% 32,214 $-240,944 Down ×3
AGIO Agios Pharmaceuticals, Inc. - Common Stock $2,616,255 1.61% 70,500 $-1,614,525 Down ×2
CBIO Crescent Biopharma, Inc. - Common Stock $2,299,842 1.42% 127,769 $-514,277 Down ×1
AZN AstraZeneca PLC - American Depositary Shares $2,254,128 1.39% 12,045 Up ×1
BSX Boston Scientific Corporation Common Stock $2,063,450 1.27% 48,347 $-970,324
ADAG Adagene Inc. - ADS, each representing 1.25 ordinary shares $2,050,831 1.27% 488,293 $-837,601 Down ×2
PEN Penumbra, Inc. Common Stock $1,989,225 1.23% 6,300 $-79,506
ISRG Intuitive Surgical, Inc. - Common Stock $1,951,813 1.20% 4,908 $-979,161 Down ×1
VKTX Viking Therapeutics, Inc. - Common Stock $1,867,058 1.15% 47,861 Up ×1
OCUL Ocular Therapeutix, Inc. - Common Stock $1,783,194 1.10% 181,588 Up ×1
EQ Equillium, Inc. - Common Stock $1,769,459 1.09% 552,956 Up ×1
Unknown issuer (CUSIP: K08588103) $1,753,151 1.08% 6,573 Up ×1
CRBP Corbus Pharmaceuticals Holdings, Inc. - Common Stock $1,734,493 1.07% 184,914 $-464,044 Down ×1
CTMX CytomX Therapeutics, Inc. - Common Stock $1,725,251 1.06% 460,067 $-725,649 Down ×2
VSTM Verastem, Inc. - Common Stock $1,638,937 1.01% 429,041 $-1,735,573 Down ×1
NKTR Nektar Therapeutics - Common Stock $1,564,931 0.97% 22,417 Up ×1
CLPT ClearPoint Neuro Inc. - Common Stock $1,492,066 0.92% 83,636 Up ×1
INSM Insmed Incorporated - Common Stock $1,479,139 0.91% 13,873 $-2,878,833 Down ×1
CAI Caris Life Sciences, Inc. - Common Stock $1,393,168 0.86% 78,180 Up ×1
BBIO BridgeBio Pharma, Inc. - Common Stock $1,367,378 0.84% 18,359 $-3,644,578 Down ×6
ZBIO Zenas BioPharma, Inc. - Common Stock $1,331,003 0.82% 52,443 $-247,269 Down ×1
NBP NovaBridge Biosciences - American Depositary Shares $1,125,072 0.69% 576,960 $-294,250
ESTA Establishment Labs Holdings Inc. - Common Shares $1,124,111 0.69% 13,100 $380,293
RLAY Relay Therapeutics, Inc. - Common Stock $889,305 0.55% 47,531 $-1,879,800 Down ×1
GERN Geron Corporation - Common Stock $798,779 0.49% 624,046
DRUG Bright Minds Biosciences Inc. - common stock $709,722 0.44% 10,110 Up ×1
CMPX Compass Therapeutics, Inc. - Common Stock $604,801 0.37% 276,165 Up ×1
REPL Replimune Group, Inc. - Common Stock $446,796 0.28% 40,361
ABUS Arbutus Biopharma Corporation - Common Stock $240,797 0.15% 50,166 $-98,881 Down ×1

Biggest new bets

09

New positions opened this quarter, largest first.

SecurityValueShares% of portfolio
TGTX $9,060,430 164,915 5.59%
ABVX $6,246,962 46,878 3.85%
QURE $3,733,439 81,056 2.30%
AZN $2,254,128 12,045 1.39%
VKTX $1,867,058 47,861 1.15%
OCUL $1,783,194 181,588 1.10%
EQ $1,769,459 552,956 1.09%
Unknown issuer (CUSIP: K08588103) $1,753,151 6,573 1.08%
NKTR $1,564,931 22,417 0.97%
CLPT $1,492,066 83,636 0.92%
CAI $1,393,168 78,180 0.86%
GERN $798,779 624,046 0.49%
DRUG $709,722 10,110 0.44%
CMPX $604,801 276,165 0.37%
REPL $446,796 40,361 0.28%

Top movers (QoQ)

10
SecurityActionShares ΔValue Δ
PRAX Trimmed -18K -$5.5M
BBIO Trimmed -49K -$3.6M
ELVN Trimmed -120K -$3.5M
INSM Trimmed -13K -$2.9M
COGT Trimmed -68K -$2.6M
GH Trimmed -15K +$2.5M
RLAY Trimmed -231K -$1.9M
VSTM Trimmed -208K -$1.7M
CYTK Trimmed -44K -$1.7M
AGIO Trimmed -55K -$1.6M

Exited positions

11

Includes corporate events (mergers, delistings) — not all exits are sells

Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.

SecurityQuarterShares beforeValue beforePrice since exit
XBI June 30, 2026 60,000 $7,663,800 -3.0%
WVE March 31, 2026 421,488 $7,165,296 -49.2%
AZN March 31, 2026 28,362 $5,260,652 -19.8%
JAZZ March 31, 2026 26,494 $4,503,980 22.3%
ELV June 30, 2026 14,677 $4,296,692 2.6%
IMVT March 31, 2026 158,622 $4,032,171 31.7%
ETNB Dec. 31, 2025 273,661 $4,022,817 No longer tracked
UHS March 31, 2026 17,628 $3,843,257 -1.2%
APGE Dec. 31, 2025 94,400 $3,750,512 No longer tracked
IRON March 31, 2026 46,743 $3,711,862 0.3%
APLS June 30, 2026 85,517 $3,440,349 No longer tracked
CELC March 31, 2026 34,289 $3,419,985 -36.1%
TVTX March 31, 2026 89,052 $3,402,677 92.5%
DXCM March 31, 2026 50,147 $3,328,256 34.7%
CVS Dec. 31, 2025 43,600 $3,287,004 8.5%
SLNO Dec. 31, 2025 48,445 $3,274,882 No longer tracked
SRRK Sept. 30, 2025 84,339 $2,987,287 16.5%
VRDN June 30, 2025 217,294 $2,929,123 35.0%
AKRO Dec. 31, 2025 58,579 $2,781,331 No longer tracked
PPH Dec. 31, 2025 30,000 $2,710,800 7.9%
IMCR March 31, 2026 76,750 $2,663,993 -1.7%
GERN Dec. 31, 2025 1,858,354 $2,545,945 -6.8%
VSTM Sept. 30, 2025 599,900 $2,489,585 -8.3%
EWTX March 31, 2026 100,046 $2,482,641 29.6%
AVTX June 30, 2026 159,341 $2,378,961 -25.0%
SVRA June 30, 2025 836,397 $2,316,819 108.8%
BLTE March 31, 2026 14,328 $2,291,907 -2.9%
WAY March 31, 2026 68,969 $2,258,735 8.4%
IRWD March 31, 2026 648,532 $2,185,553 4.4%
KPTI March 31, 2026 295,541 $2,175,182 -88.1%
CNTA Dec. 31, 2025 88,024 $2,134,582 No longer tracked
SLNO June 30, 2026 61,673 $2,064,812 No longer tracked
GEHC June 30, 2025 25,400 $2,050,034 -11.8%
COR Dec. 31, 2025 6,000 $1,875,180 -7.0%
DYN Sept. 30, 2025 195,933 $1,865,282 22.3%
RGNX Sept. 30, 2025 226,060 $1,855,953 -20.3%
SNDX Dec. 31, 2025 117,783 $1,812,091 -16.3%
CRNX Sept. 30, 2025 62,700 $1,803,252 No longer tracked
IMNM June 30, 2025 263,841 $1,775,650 120.9%
ONC June 30, 2025 6,500 $1,769,105 50.1%
UPB March 31, 2026 64,845 $1,760,542 -47.9%
APLS Sept. 30, 2025 98,600 $1,706,766 No longer tracked
RDY June 30, 2025 117,500 $1,549,825 -17.7%
BCRX Sept. 30, 2025 172,883 $1,549,032 7.0%
NKTR June 30, 2025 2,232,453 $1,518,068 57.3%
CLDX Sept. 30, 2025 73,000 $1,485,550 22.1%
ORIC Dec. 31, 2025 120,644 $1,447,728 47.7%
PRCT Dec. 31, 2025 39,900 $1,424,031 -44.5%
GOSS March 31, 2026 451,699 $1,400,267 -59.2%
INSP Dec. 31, 2025 18,600 $1,380,120 -24.9%
ARVN June 30, 2025 195,295 $1,370,971 0.8%
QURE Dec. 31, 2025 22,090 $1,289,393 -7.1%
MLTX Dec. 31, 2025 178,084 $1,276,862 -14.2%
AVTX Dec. 31, 2025 100,036 $1,271,458 -23.7%
IKT March 31, 2026 600,000 $1,230,000 18.5%
FDMT June 30, 2026 130,564 $1,215,551 -2.4%
NXTC June 30, 2026 115,500 $1,215,060 225.6%
IQV March 31, 2026 5,378 $1,212,255 55.3%
THC March 31, 2026 6,084 $1,209,012 38.8%
GPCR Sept. 30, 2025 53,744 $1,114,651 -1.3%
PALI June 30, 2026 600,000 $1,050,000 -27.5%
FULC March 31, 2026 92,055 $1,041,142 -51.5%
LEGN Sept. 30, 2025 29,100 $1,032,759 -41.4%
TRVI June 30, 2025 163,738 $1,029,912 147.7%
BHVN June 30, 2025 39,900 $959,196 -11.1%
MBX Dec. 31, 2025 52,402 $917,035 83.0%
ALVO Sept. 30, 2025 78,372 $714,753 -25.7%
NAMS Sept. 30, 2025 36,574 $662,355 -20.8%
CMPS Sept. 30, 2025 213,544 $597,923 104.5%
LPCN June 30, 2026 60,861 $486,279 -19.1%
RAPT March 31, 2026 14,194 $480,751 No longer tracked
UNH Sept. 30, 2025 1,400 $436,758 8.6%
ACAD Dec. 31, 2025 20,000 $426,800 -24.8%
AKBA June 30, 2025 189,087 $363,047 -75.2%
VYNE Sept. 30, 2025 208,970 $344,801 No longer tracked
TIL Sept. 30, 2025 16,200 $337,446 -60.9%
ANAB Sept. 30, 2025 15,000 $333,000 58.8%
ELDN Sept. 30, 2025 114,145 $309,333 -3.3%
REPL Dec. 31, 2025 73,614 $308,443 37.6%
VTYX Dec. 31, 2025 60,600 $188,466 No longer tracked
NUVB June 30, 2025 96,311 $169,507 153.3%
IMUX Dec. 31, 2025 173,900 $153,310 1421.5%
APRE June 30, 2025 28,972 $59,103 -61.1%
ELEV Sept. 30, 2025 110,353 $40,511 No longer tracked
ATYR Dec. 31, 2025 40,000 $28,840 -62.5%